Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
The perception of nurses and doctors on a care bundle guideline for management of pain in critical care [PDF]
, 2013 Objetivo: el objetivo de este estudio fue explorar la percepción de las enfermeras y los médicos sobre el uso de un paquete de aten- ción como una guía para el manejo del dolor en cuidados críticos.
Judith Lathlean +4 more
core +1 more source
Agenda for a Critical Exploration of Current Problems in Medical Care [PDF]
, 1953 E. M. Bluestone
openalex +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
Overcoming Financial Barriers to Expanding High-Quality Early Care and Education in Southeastern Pennsylvania [PDF]
, 2015 High-quality early care and education (ECE) programs have been proven to create positive outcomes for children -- especially among those living in poverty.
Alex Epps +2 more
core
Efficacy and Safety of Pediatric Critical Care Physician Telemedicine Involvement in Rapid Response Team and Code Response in a Satellite Facility [PDF]
, 2019 OBJECTIVES: Satellite inpatient facilities of larger children's hospitals often do not have on-site intensivist support. In-house rapid response teams and code teams may be difficult to operationalize in such facilities.
Berrens, Zachary J. +3 more
core +1 more source
Scientific publications in critical care medicine journals from East Asia: a 10-year survey of the literature [PDF]
, 1969 Zhenyu Cao
openalex +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Identification of factors that support successful implementation of care bundles in the acute medical setting: a qualitative study [PDF]
, 2017 Background Clinical guidelines offer an accessible synthesis of the best evidence of effectiveness of interventions, providing recommendations and standards for clinical practice.
Bell, D, Green, SA, Mays, N
core +3 more sources
Public Health Aspects of Critical Care Medicine and Anesthesiology [PDF]
, 1975 David J. Cullen
openalex +1 more source