Results 121 to 130 of about 10,286,525 (296)

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

D-PRISM: a global survey-based study to assess diagnostic and treatment approaches in pneumonia managed in intensive care

Background: Pneumonia remains a significant global health concern, particularly among those requiring admission to the intensive care unit (ICU). Despite the availability of international guidelines, there remains heterogeneity in clinical management ...
Buetti N., Sheehan E., Avanti K., Eshwara V.K., Serrano-Mayorga C.C., Hayashi Y., Tsuji I., Bracht H., Fatoni A.Z., Mer M., Shrestha G.S., Nasa P., Zangana G., Tabah A., De Bus L., bin Sulaiman H., Prieto V.E., Korkmaz P., Ait Hssain A., Reyes L.F., Abidi K., Zhang Z., De Pascale G.   +22 more
core   +1 more source

Analysis of Home Care Supports Funded by the HSE 2008–2016 [PDF]

, 2016
This paper seeks to summarise the situation of publicly funded home care over the period 2008- 2016. Of particular interest is the overall change to the level of resources being directed to home care in the 2016 HSE Service Plan, in particular the actual
Care Alliance Ireland
core  

Intracellular ATP Levels in CD4+ T Lymphocytes as a Prognostic Marker for 28-Day Mortality in Adult ICU Patients with Sepsis: A Retrospective Study

Journal of Inflammation Research
Lijing Fan, Hongbin Hu, Zhili Liang, Yujie Cai, Qingfen Liu, Siyi Li, Weidang Xie, Zhimin Zou, Yanan LiuDepartment of Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, People’s Republic of China&ast ...
Fan L, Hu H, Liang Z, Cai Y, Liu Q, Li S, Xie W, Zou Z, Liu Y   +8 more
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Safety and Efficacy of Nebulized Inhalation of Polymyxin B Sulfate for Carbapenem-Resistant Gram-Negative Bacterial Pneumonia: A Multi-Center, Prospective, Observational Study

Infection and Drug Resistance
Meifei Zhu,1,* Jiaying Zhang,1,* Yijiao Han,2,* Xia Zheng,2 Qianghong Xu,3 Qingyong Chen,4 Shi Chen,5 Yinan Yao,6 Ronglin Jiang,1 Jiannong Wu,1 Hua Zhou,7 Shu Lei1 1Department of Critical Care Medicine, The First Affiliated ...
Zhu M, Zhang J, Han Y, Zheng X, Xu Q, Chen Q, Chen S, Yao Y, Jiang R, Wu J, Zhou H, Lei S   +11 more
doaj