Results 141 to 150 of about 2,111,707 (269)

The Vigilance Gradient: Nine Years of Adverse Event Trends in Pediatric Critical Care. [PDF]

Crit Care Explor
Singh D, Miller MR, Patel MA, Anderson C, Fraser DD.   +4 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

"It Is Humble but Honorable Work": A Needs Assessment of Critical Care Education in the Pediatric Residency Programs of Honduras. [PDF]

J Grad Med Educ
Napky Raudales PJ, Jimenez-Zambrano A, Velasquez SY, Anariba DC, Rodriguez SL, Marie GH, Wilson PT, Czaja AS.   +7 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Multimodal Artificial Intelligence for Precision Critical Care: A Scoping Review. [PDF]

Health Data Sci
Yang M, Shi N, Chen H, Po EYP, Ng PY, Lai PCK, Wu YC, Fong DYT.   +7 more
europepmc   +1 more source

IL-27 Aggravates Sepsis-Induced ARDS by Driving Macrophage Ferroptosis Through Activation of NCOA4-Mediated Ferritinophagy

Journal of Inflammation Research
Minkang Guo,1,2 Meng Xiong,1 Jindian Shi,1 Qiaozhi Peng,1 Shihui Lin,1 Fang Xu1 1Department of Critical Care Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 2The Chongqing Key ...
Guo M, Xiong M, Shi J, Peng Q, Lin S, Xu F   +5 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Critical Care Ultrasonography for Cardiogenic Shock: A Scoping Review. [PDF]

Crit Care Explor
Sharif S, Wang K, Basmaji J, Ablordeppey E, Díaz-Gómez JL, Lanspa M, Nikravan S, Lewis K.   +7 more
europepmc   +1 more source

Development and Validation of a Prediction Model for Intensive Care Unit-Acquired Weakness in Adult Patients with Sepsis: A Prospective, Observational, Single-Center Study

International Journal of General Medicine
Binghan Wang,1,* Yuting Liu,1,* Guilan He,2 Sha Sun,1 Jianqiang Han,1 Min Zhang,1 Linna He,1 Siya Meng1 1Department of Critical Care Medicine, Shenzhen Nanshan People’s Hospital, Shenzhen, 518000, People’s Republic of China; 2Party and ...
Wang B, Liu Y, He G, Sun S, Han J, Zhang M, He L, Meng S   +7 more
doaj  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source