Results 151 to 160 of about 5,260,453 (314)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

INTENSIVE CRITICAL CARE

Lung India, 2022
openaire   +2 more sources

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Prognostic Value of SIRI in Sepsis: A Retrospective Study and Machine Learning-Based Model Development

Journal of Inflammation Research
Yilin Zhu,1,* Zhiyang Wang,2,* Shifeng Li,3,* Xin Xiao,3 Yujie Liu,3 Jiachen He,3 Fang Huang,3 Jun Wang3 1Department of Critical Care Medicine, Zhangjiagang Hospital Affiliated to Soochow University/The First People’s Hospital of ...
Zhu Y, Wang Z, Li S, Xiao X, Liu Y, He J, Huang F, Wang J   +7 more
doaj  

Automating Critical Care EEG: Enhancing Accuracy, Efficiency, and Patient Outcomes in Critical Care. [PDF]

Epilepsy Curr
Rubinos C, Amorim E, Rehim E, Rodriguez-Ruiz A, Zafar SF, Sheikh ZB, Bruzzone MJ.   +6 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Antifreeze Poisoning Complicated by Severe Metabolic Acidosis, Toxic Encephalopathy, and Multiple Organ Dysfunction Syndrome: A Case Report

Open Access Emergency Medicine
Min Liu,1– 3 Yayuan Tan,1– 3 Yinchun Xie,1,4 Jinglan Liu,1– 3 Haishuang Mei,1– 3 Dan Jin,1– 3 Zhaohui Zhang1– 3 1Department of Intensive Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, People’s ...
Liu M, Tan Y, Xie Y, Liu J, Mei H, Jin D, Zhang Z   +6 more
doaj  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Artificial intelligence in emergency medicine critical care. [PDF]

Clin Exp Emerg Med
Heslin SM, Nocito R, Weingart SD.
europepmc   +1 more source