Results 171 to 180 of about 12,324,592 (318)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

The Vigilance Gradient: Nine Years of Adverse Event Trends in Pediatric Critical Care. [PDF]

Crit Care Explor
Singh D, Miller MR, Patel MA, Anderson C, Fraser DD.   +4 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Identification of developing multiple organ failure in sepsis patients with low or moderate SOFA scores

Critical Care, 2018
Gunnar Elke, Frank Bloos, Darius Cameron Wilson, Patrick Meybohm, the SepNet Critical Care Trials Group   +4 more
doaj   +1 more source

Critical Care Ultrasonography for Cardiogenic Shock: A Scoping Review. [PDF]

Crit Care Explor
Sharif S, Wang K, Basmaji J, Ablordeppey E, Díaz-Gómez JL, Lanspa M, Nikravan S, Lewis K.   +7 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Uncovering Research Themes in Simulation-Based Critical Care Education: A Bibliometric and Cluster Analysis. [PDF]

Nurs Crit Care
Li L, Lv Y, Dong L.
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Ginsenoside Rg3 Mitigates LPS-Induced Injury in Human Bronchial Epithelial Cells by Restoring Autophagic Flux and Inhibiting the TLR4/NF-κB-Mediated Inflammatory Response

Journal of Inflammation Research
Xingyu Tao,1– 4,* Lingjiao Liu,1– 3,* Xiaoke Gu,5 Baohui Jia,6 Qi Yu,1– 3 Yingying Wei,1– 3 Wei Zhang,1– 3 Jing Zhou1– 3 1Department of Respiratory and Critical Care Medicine, Jiangxi Medical College, Nanchang University, The First ...
Tao X, Liu L, Gu X, Jia B, Yu Q, Wei Y, Zhang W, Zhou J   +7 more
doaj  

Variability in first academic medicine job offers in pulmonary and critical care medicine. [PDF]

ATS Sch
Olson EM, Modes ME, Rowe TJ, Lyons PG, Ingraham NE, Nadig NR, Schroedl CJ, Gao CA.   +7 more
europepmc   +1 more source