Results 191 to 200 of about 2,111,707 (269)

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Socioeconomic Status, Rurality, and Pediatric Critical Care Admission.

JAMA Netw Open
Bone JN, Shen Y, Harden S, Retallack J, Carwana M, Murthy S, Muttalib F.   +6 more
europepmc   +1 more source

The Actionable Innovation Day Approach: Participatory Model for Advancing Critical Care Innovation. [PDF]

J Med Internet Res
Hryciw BN, Tran C, Ramchandani R, Love C, Caron C, Sarti A, Miller A, Madore S, Chasse M, Pan A, Didcote S, Millington S, Galley H, Kyeremanteng K, Seely A.   +14 more
europepmc   +1 more source

Effect of Statin Use on Mortality in Individuals With Cardiovascular–Kidney–Metabolic Syndrome: A Retrospective Propensity Score-Matched Cohort Study

Cardiovascular Therapeutics
Cheng Yuan, Yuguo Ge, Wenqi Ge, Huaxue Wang, Ximing Deng, Jinmeng Chen, Kaixuan Niu, Jinhui Xiong, Yang Xu, Kun Lu   +9 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Electroencephalogram Monitoring in Critical Care: Multicenter Analysis of Timing, Duration, and Readmissions. [PDF]

Crit Care Explor
Tăuțan AM, Sarami M, Sartipi S, Turley N, Gupta A, Ghanta M, Fernandes MP, Mitra A, Kim J, Struck AF, Westover MB, Zafar SF.   +11 more
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Act now: strengthening critical care readiness in fragile health systems during war and disasters. [PDF]

Crit Care
Elmi AH.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source