Results 101 to 110 of about 5,260,453 (314)

Deciphering Cuproptosis in Sepsis: Mechanisms, Consequences, and Therapeutic Opportunities

Journal of Inflammation Research
Ruimin Tan,1,2 Kexin Wen,1,2 Tianyu Zhao,2,3 He Guo,2,4 Xumin Han,2,4 Jiakai Wang,2,4 Chen Ge,2 Quansheng Du2 1School of Clinical Medical, North China University of Science and Technology, Tangshan, Hebei, People’s Republic of China; 2Critical Care ...
Tan R, Wen K, Zhao T, Guo H, Han X, Wang J, Ge C, Du Q   +7 more
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Profiling Physiotherapy in Australian and New Zealand Intensive Care [PDF]

, 2008
Physiotherapy for ICU patients is considered essential by many health professionals and professional bodies, yet the evidence base for this service is insufficient. No published research outlining optimal management of this service exist.
Leslie, Kristin, Patman, Shane
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Septic Shock and Multiorgan Failure Related to Liver Abscess Caused by Fish Bone Penetration of Duodenal Wall

Case Reports in Gastrointestinal Medicine
We report an intriguing case of an 80-year-old male presented with high-grade fever and severe upper abdominal pain. An abdominal ultrasound indicated a deep-seated abscess in the Segment IV of liver. An elusive diagnosis was made after Contrast Enhanced
Md. Atiquzzaman, Injamam Ull Haque, Md Motiul Islam, Tarikul Hamid, Mohammad Rabiul Halim, Kazi Nuruddin Ahmed, Sadia Jesmin, Rajib Hasan, Quazi Abdullah Al Masum, Md. Ashikuzzaman Sohan   +9 more
doaj   +1 more source

Critical Care

Surgical Clinics of North America, 2022
openaire   +2 more sources

An Analysis of Major Issues for Culturally-Minded Professionals in Women\u27s Health Care [PDF]

, 2019
Women\u27s health care professionals, such as general physicians, obstetricians and gynecologists, midwives, nurses, and doulas, in the US need to be aware of cultural issues and disparities.
Clark, Victoria
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source