Results 81 to 90 of about 12,324,592 (318)

COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland

Intensive Care Medicine, 2020
To describe critical care patients with COVID-19 across England, Wales and Northern Ireland and compare them with a historic cohort of patients with other viral pneumonias (non-COVID-19) and with international cohorts of COVID-19.
Alvin Richards-Belle, I. Orzechowska, D. Gould, K. Thomas, J. Doidge, P. Mouncey, M. Christian, M. Shankar-Hari, D. Harrison, K. Rowan, Yemi Kasia Tom Peter Keji Robert Hanna Laura Andrew Dit Banjo Borowczak Cousins Cummins Dalemo Darnell Dem, Y. Banjo, Kasia Borowczak, Tom Cousins, Pete Cummins, Keji Dalemo, Robert Darnell, Hanna Demissie, Laura Drikite, Andrew Fleming, Ditte Frederiksen, S. Furnell, Abdo Hussein, A. Koelewyn, Tim Matthews, S. Peters, T. Samuels, M. Saull   +27 more
semanticscholar   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Renal venous flow in different regions of the kidney are different and reflecting different etiologies of venous reflux disorders in septic acute kidney injury: a prospective cohort study

Intensive Care Medicine Experimental
Background Acute kidney injury (AKI) is a frequent complication of sepsis. While impaired renal venous reflux indicates renal congestion, the relationship between AKI outcomes and hemodynamic parameters remains debated.
Rongping Chen, Hui Lian, Hua Zhao, Xiaoting Wang, and Critical Care Ultrasound Study Group   +4 more
doaj   +1 more source

A Core Outcome Set for Pediatric Critical Care

Critical Care Medicine, 2020
Objective More children are surviving critical illness but are at risk of residual or new health conditions. An evidence-informed and stakeholder-recommended core outcome set is lacking for pediatric critical care outcomes.
E. Fink, A. Maddux, N. Pinto, Samuel Sorenson, D. Notterman, J. Dean, J. Carcillo, R. Berg, A. Zuppa, M. Pollack, K. Meert, M. Hall, A. Sapru, P. McQuillen, Peter M. Mourani, D. Wessel, D. Amey, A. Argent, W. D. de Carvalho, W. Butt, K. Choong, M. Curley, Maria del Pilar Arias López, D. Demirkol, R. Grosskreuz, A. Houtrow, H. Knoester, J. Lee, D. Long, J. Manning, B. Morrow, J. Sankar, B. Slomine, McKenna Smith, L. Olson, R. Watson   +35 more
semanticscholar   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The Value of Glycemic Gap for Predicting Mortality in ICU in Patients With and Without Diabetes

Journal of Diabetes Research
Conclusion: The glycemic GAP between the mean level of blood glucose within the first 7 days in ICU and ADAG was independently associated with 28-day mortality of critically ill patients, which was different between patients with and without diabetes ...
Ran Lou, Li Jiang, Meiping Wang, Tingting Wang, Quan Si, Weixue Su, Nan Wang, Yuyan Liu, Ting Chen, Qi Jiang, Bo Zhu   +10 more
doaj   +1 more source

Gender Differences in Authorship of Critical Care Literature.

American Journal of Respiratory and Critical Care Medicine, 2020
RATIONALE Gender gaps exist in academic leadership positions in critical care. Peer-reviewed publications are crucial to career advancement, yet little is known regarding gender differences in authorship of critical care research.
K. Vranas, David Ouyang, A. Lin, C. Slatore, D. Sullivan, Meeta Prasad Kerlin, Kathleen D. Liu, R. Baron, C. Calfee, L. Ware, S. Halpern, M. Matthay, M. Herridge, S. Mehta, A. Rogers   +14 more
semanticscholar   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source