Results 71 to 80 of about 12,324,592 (318)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Critical care management of adults with community-acquired severe respiratory viral infection

Intensive Care Medicine, 2020
With the expanding use of molecular assays, viral pathogens are increasingly recognized among critically ill adult patients with community-acquired severe respiratory illness; studies have detected respiratory viral infections (RVIs) in 17–53% of such ...
Y. Arabi, R. Fowler, F. Hayden
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Sepsis induced coagulopathy (SIC): is it monolithic?

Thrombosis Journal
Introduction Sepsis-induced coagulopathy (SIC) is known to be linked with an increased mortality of sepsis. Methods We designed this study to investigate whether there is heterogeneity in the clinical manifestations of SIC between cases with ...
Lu Wang, Xiang Zhou, China National Critical Care Quality Control Centre Group (China-NCCQC)   +2 more
doaj   +1 more source

Clinical Value of FeNO for Pulmonary Hypertension Diagnosis in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Emergency Medicine International, 2022
Objective. To investigate the clinical value of fractional exhaled nitric oxide (FeNO) in the diagnosis of pulmonary hypertension (PH) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods.
Wei Guo, Ning Wang, Zhaobo Cui, Wenjing Liu, Shufen Guo, Xiaoya Yang, Yajing Liu, Liye Shao, Jing Wang   +8 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Association of Albumin–Bilirubin (ALBI) Grade With 28-Day All-Cause Mortality in Patients With Acute Respiratory Distress Syndrome: A Retrospective Analysis of the MIMIC-IV Database

Mediators of Inflammation
The albumin–bilirubin (ALBI) grade, a validated prognostic tool in cancers such as hepatocellular carcinoma, has not been evaluated in acute respiratory distress syndrome (ARDS).
Weixiao Chen, Qingzhou Chen, Zhiwei Tang, Zhibo Li, Weiyan Chen, Xuming Xiong, Deliang Wen, Zhenhui Zhang   +7 more
doaj   +1 more source

From critical care nephrology to critical care blood purification [PDF]

Journal of Translational Internal Medicine, 2021
Yang, Rongli, Chen, Xiukai, Li, Suwei, Wang, Xiaoting, Liu, Dawei   +4 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Human-to-Human Transmission of Severe Fever With Thrombocytopenia Syndrome Resulting in Fatal Cases: A Case Series

Case Reports in Infectious Diseases
Severe fever with thrombocytopenia syndrome (SFTS), primarily a tick-borne disease, can also cause fatal human-to-human transmission. This report analyzes a cluster of six SFTS cases identified in China in 2022, involving one index patient and five ...
Lu Yao, Xiaobo Yang, Xuehui Gao, Yin Yuan, Chang Li, Chenggang Gao, Huaqing Shu, Xiaojing Zou, Ruiting Li, Jiqian Xu, You Shang   +10 more
doaj   +1 more source