Results 111 to 120 of about 1,997,752 (267)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Diagnostic Utility of Pentraxin 3 Expression in Septic Cardiomyopathy: Findings from a Prospective Observational Study

Journal of Inflammation Research
Na Cui,1,2,* Xiao-Wei Lv,2,* Teng-Hao Shao,2 Zhan-Biao Yu,2 Zhi Chen,2 Tao Sun,2 Tie-Min Li,2 Jin-Wen Zhang,2 Zhen-Jie Hu1 1Department of Critical Care Medicine, The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang ...
Cui N, Lv XW, Shao TH, Yu ZB, Chen Z, Sun T, Li TM, Zhang JW, Hu ZJ   +8 more
doaj  

The Impact of Hand Edema on Weaning From Mechanical Ventilation in ICU Patients: A Single Center Nested Case-Control Study

International Journal of Clinical Practice
Conclusion: The occurrence of hand edema in ICU patients on mechanical ventilation increases the risk of weaning failure.
Dingye Wu, Junfeng Heng, Fengming Liang, Tao Zhou, Qiuhui Wang, Hongyang Xu   +5 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Intravenous iron to treat anaemia following critical care: a multicentre feasibility randomised trial

, 2021
Akshay Shah, Mae Chester‐Jones, Susan Dutton, Ioana R. Marian, Vicki S Barber, David Griffith, Jo Singleton, Katherine Wray, Tim James, Hal Drakesmith, Peter A. Robbins, Matthew Frise, Duncan Young, Timothy Walsh, Stuart McKechnie, Simon Stanworth, Paula Hutton, Archana Bashyal, George Chapman, Killian Donovan, Christie James, Nicola Rea, Sarah L. Clark, Lucy Barclay, Kate Priestley, David Hope, Corrienne McCulloch, Nicola Jacques, Shauna Bartley, Parminder Bhachu, Joanna Black, Emma Haines, Lucy Eldridge, Quentin A. Hill, Andrew Walden, Toby Richards   +35 more
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Treatment strategy for compartment syndrome at multiple regions due to injuries caused by a tree fall: a case report

International Journal of Emergency Medicine
Background Compartment syndrome commonly occurs in patients with forearm and lower leg fractures. Compartment syndromes of the gluteal and thigh muscles are less common.
Tomotaka Miura, Takahito Miyake, Hideshi Okada, Hideaki Oiwa, Yosuke Mizuno, Yuichiro Kitagawa, Tetsuya Fukuta, Haruka Okamoto, Masato Shiba, Norihide Kanda, Takahiro Yoshida, Shozo Yoshida, Shinji Ogura   +12 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Racial and ethnic disparities in psychological care for individuals with FASD: a dis/ability studies and critical race theory perspective toward improving prevention, assessment/diagnosis, and intervention [PDF]

Madeline N. Rockhold, Blake A. Gimbel, A. Richardson, Carson Kautz‐Turnbull, Emily Speybroeck, Erik de Water, Julianne Myers, Emily Hargrove, M. El May, Samia S. Abdi, Christie L. M. Petrenko   +10 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source