Results 111 to 120 of about 14,005,591 (363)

Antimicrobial-associated harm in critical care: a narrative review

Intensive Care Medicine, 2020
The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to improved stewardship of these vital agents.
N. Arulkumaran, M. Routledge, S. Schlebusch, J. Lipman, A. Conway Morris   +4 more
semanticscholar   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

1939 How can we improve the transition process of children and young people to adult critical care? [PDF]

, 2022
Mehrengise Cooper, Rum Thomas, Clare Windsor, Tim Wenham   +3 more
openalex   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

Comparison of two Norepinephrine rescue bolus for Management of Post-spinal Hypotension during Cesarean Delivery: a randomized controlled trial

BMC Anesthesiology, 2020
Background Data on the best norepinephrine bolus dose for management of hypotension are limited. The aim of this study was to compare the efficacy and safety of two norepinephrine bolus doses in the rescue management of maternal hypotension during ...
Yasmin S. Hassabelnaby, Ahmed M. Hasanin, Nada Adly, Maha M. A. Mostafa, Sherin Refaat, Eman Fouad, Mohamed Elsonbaty, Hazem A. Hussein, Mohamed Mahmoud, Yaser M. Abdelwahab, Ahmed Elsakka, Sarah M. Amin   +11 more
doaj   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

The Causal Relationship between Plasma Myeloperoxidase Levels and Respiratory Tract Infections: A Bidirectional Mendelian Randomization Study

Mediators of Inflammation
Background. Observational researches reported the underlying correlation of plasma myeloperoxidase (MPO) concentration with respiratory tract infections (RTIs), but their causality remained unclear.
Xiu Liu, Chuchu Zhang, Jiajia Ren, Guorong Deng, Xi Xu, Jueheng Liu, Xiaoming Gao, Ruohan Li, Jiamei Li, Gang Wang   +9 more
doaj   +1 more source

Screening general population for family history of sudden cardiac death unmasks high risk individuals as potential victims (pilot study)

Egyptian Journal of Critical Care Medicine, 2018
As there are no large scale Egyptian surveys estimating the prevalence of cardiac disease and the incidence of SCD in a non-selected population, the purpose of this report was to assess the relation between family history of SCD and the presence of CAD ...
Lamia Hamid, Alia Abdelfattah, Khaled Hussien, Khaled Farouk, Mohamed Amin, Lina Omar, M. Sherif Mokhtar   +6 more
doaj   +1 more source

Control of Confounding and Reporting of Results in Causal Inference Studies. Guidance for Authors from Editors of Respiratory, Sleep, and Critical Care Journals

Annals of the American Thoracic Society, 2019
Control of Confounding and Reporting of Results in Causal Inference Studies Guidance for Authors fromEditors of Respiratory, Sleep, andCritical Care Journals David J. Lederer*, Scott C. Bell*, Richard D. Branson*, James D.
D. Lederer, S. Bell, R. Branson, J. Chalmers, R. Marshall, D. Maslove, D. Ost, N. Punjabi, M. Schatz, A. Smyth, P. Stewart, S. Suissa, A. Adjei, C. Akdis, É. Azoulay, J. Bakker, Z. Ballas, P. Bardin, E. Barreiro, R. Bellomo, J. Bernstein, V. Brusasco, T. Buchman, S. Chokroverty, N. Collop, J. Crapo, D. Fitzgerald, L. Hale, N. Hart, F. Herth, T. Iwashyna, G. Jenkins, M. Kolb, G. Marks, P. Mazzone, R. Moorman, T. Murphy, T. Noah, Paul R Reynolds, D. Riemann, R. Russell, A. Sheikh, G. Sotgiu, E. Swenson, R. Szczesniak, R. Szymusiak, J. Teboul, J. Vincent   +47 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source