Results 151 to 160 of about 13,388,670 (413)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Effects of Esketamine Versus Remifentanil on Hemodynamics and Prognosis in Patients with Septic Shock Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

open access: yesDrug Design, Development and Therapy
Yuting Li, Hongxiang Li, Feng Zhang, Yumeng Chen, Dong Zhang Department of Critical Care Medicine, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Dong Zhang, Email zhangdong@jlu.edu.cnBackground ...
Li Y, Li H, Zhang F, Chen Y, Zhang D
doaj  

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

open access: yesMolecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Critical Care Medicine Handbook [PDF]

open access: bronze, 1976
Mareike Weil, H Shubin
openalex   +1 more source

Critical care archetypes [PDF]

open access: yesCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 2021
Paul A. Cameron, Wael Haddara
openaire   +2 more sources

Telemedicine coverage for post-operative ICU patients. [PDF]

open access: yes, 2017
Introduction There is an increased demand for intensive care unit (ICU) beds. We sought to determine if we could create a safe surge capacity model to increase ICU capacity by treating ICU patients in the post-anaesthesia care unit (PACU) utilizing a ...
Collins, Tara Ann   +6 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

open access: yesMolecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen   +12 more
wiley   +1 more source

Prediction of Critical Illness During Out-of-Hospital Emergency Care

open access: yes, 2010
CONTEXT: Early identification of nontrauma patients in need of critical care services in the emergency setting may improve triage decisions and facilitate regionalization of critical care.
Cooke, Colin   +5 more
core   +1 more source

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