Results 151 to 160 of about 14,005,591 (363)

Endotracheal Oxygen Insufflation Associated with Life-Threatening Barotrauma during Apnea Testing

Case Reports in Neurological Medicine
Apnea testing is a standard method when diagnosing brain or more specifically brainstem death; however, it is imperative to acknowledge the potential for lung injury during this procedure and follow clinical practice guideline recommendations that may ...
Saud Ali Aljasir, Fahad Abdullah Alshammari, Jehan Abdullah Abdul-aziz Fatani, Abdalrhman Al Saadon, Abdulaziz H. Alzeer   +4 more
doaj   +1 more source

Adolescent Health Services: Missing Opportunities [PDF]

, 2008
Examines the status of adolescents' health and health services, including critical needs, promising models, and components for improving disease prevention and health promotion.
Jennifer Appleton Gootman, Leslie J. Sim, Robert S. Lawrence   +2 more
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Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Electronically Assisting Communication for Health Professionals [PDF]

, 2001
New information and computing technologies offer cost efficient and effective learning opportunities for health care professionals. The Assisted Electronic Communication project is prototyping, administering and evaluating a digital discourse system for ...
Brooks, Fiona, Macintyre, Maria, Quick, Kevin, Scott, Peter   +3 more
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Metabolomic Profiling by UPLC-QTOF/MS Reveals Potential Biomarkers and Metabolic Alterations in Pediatric Septic Shock

Journal of Inflammation Research
Changxue Xiao,* Chenhao Wang,* Sa Wang, Feng Xu, Yingfu Chen Department of Critical Care Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of ...
Xiao C, Wang C, Wang S, Xu F, Chen Y
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effects of Esketamine Versus Remifentanil on Hemodynamics and Prognosis in Patients with Septic Shock Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial

Drug Design, Development and Therapy
Yuting Li, Hongxiang Li, Feng Zhang, Yumeng Chen, Dong Zhang Department of Critical Care Medicine, The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of ChinaCorrespondence: Dong Zhang, Email zhangdong@jlu.edu.cnBackground ...
Li Y, Li H, Zhang F, Chen Y, Zhang D
doaj  

A case of hemodiafiltration dialysis preventing progression of acute kidney injury in a patient with hypermyoglobinemia in one kidney: a case report

Journal of Medical Case Reports
Background Rhabdomyolysis is a clinical syndrome resulting from skeletal muscle damage and the release of its breakdown products into the bloodstream. It can range from asymptomatic cases to severe conditions such as acute kidney injury.
Toru Minamiyama, Shozo Yoshida, Yosuke Mizuno, Hiroki Kitagaki, Kaori Kimura, Yoshihito Naito, Akihiro Uchida, Ayumi Kuroda, Yuki Kawasaki, Ayane Nishio, Hirotsugu Fukuda, Genki Yoshimura, Ryo Kamidani, Takahito Miyake, Norihide Kanda, Hideshi Okada   +15 more
doaj   +1 more source

The use of knowledge of respiratory physiology in critical care nurses' clinical decision-making : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Nursing at Massey University [PDF]

, 2005
The knowledge and experience of expert nurses has long been recognised as contributing to early identification of patient problems, early intervention and an improved patient outcome.
Pirret, Alison Margaret
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