Results 71 to 80 of about 1,997,752 (267)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Engaging primary care physicians is critical in the screening and diagnosis of colorectal cancer at safety-net hospital systems

, 2023
Katrina Dimaano, Millicent Croman, Stefania Montero, Isabela Sandigo-Saballos, Manuel Orellana, Nikhil Chervu, Beverley A. Petrie, Hanjoo Lee   +7 more
openalex   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Improving critical incident reporting in primary care through education and involvement [PDF]

, 2019
Beate S. Müller, Martin Beyer, Tatjana Blazejewski, Dania Gruber, Hardy Müller, Ferdinand M. Gerlach   +5 more
openalex   +1 more source

The rapid development and deployment of a new multidisciplinary CPAP service outside of a critical care environment during the early stages of the COVID-19 pandemic

, 2021
Ryan Robinson, Rebecca Nightingale, Freddy Frost, Tom Green, Gareth Jones, Nneka Nwosu, Peter Hampshire, Deborah Brown, Michael Beadsworth, Stephen Aston, Angela Gillespie, Mark Clark, Tom Fletcher, Neil Haslam, Hassan Burhan, Manish Kumar Gautam   +15 more
openalex   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Get To The Point! Problem-Based Curated Data Views To Augment Care For Critically Ill Patients [PDF]

, 2022
Minfan Zhang, Daniel Ehrmann, Mjaye Mazwi, Danny Eytan, Marzyeh Ghassemi, Fanny Chevalier   +5 more
openalex   +1 more source

A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis

Journal of Inflammation Research
Meili Liu,1,2,* Tao You,3,* Shifeng Li,1,* Yan Hao,1,* Zhiyang Wang,1 Fang Huang,1 Jun Wang1 1Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China ...
Liu M, You T, Li S, Hao Y, Wang Z, Huang F, Wang J   +6 more
doaj  

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Critical Care Transport of Patients With COVID-19 [PDF]

, 2021
Michael A. Frakes, Jeremy B. Richards, Michael N. Cocchi, Ari Cohen, Jason Cohen, James Dargin, Franklin D. Friedman, Adam Kaye, Jordan S. Rettig, Raghu R. Seethala, Susan R. Wilcox   +10 more
openalex   +1 more source