Results 71 to 80 of about 11,753,466 (311)

Purification tags markedly affect self‐aggregation of CPEB3

FEBS Letters, EarlyView.
Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito, Yujin Lee, Motoharu Ueno, Naotaka Sekiyama, Masatomo So, Ayako Furukawa, Kenji Sugase   +6 more
wiley   +1 more source

Machine learning for the prediction of volume responsiveness in patients with oliguric acute kidney injury in critical care

Critical Care, 2019
Background and objectivesExcess fluid balance in acute kidney injury (AKI) may be harmful, and conversely, some patients may respond to fluid challenges.
Wentao Bao, K. Ho, Yucai Hong
semanticscholar   +1 more source

British Association of Critical Care Nurses: Evidence-based consensus paper for oral care within adult critical care units.

Nursing Critical Care, 2020
BACKGROUND Patients who are critically ill are at increased risk of hospital acquired pneumonia and ventilator associated pneumonia. Effective evidence based oral care may reduce the incidence of such iatrogenic infection.
T. Collins, C. Plowright, V. Gibson, L. Stayt, Sarah Clarke, Jo Caisley, Claire Harcourt Watkins, Emily J Hodges, G. Leaver, S. Leyland, Patricia McCready, S. Millin, Julie Platten, M. Scallon, Patsy Tipene, Gabby Wilcox   +15 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Response to. comment on optic nerve sheath diameter ultrasound evaluation in intensive care unit: possible role and clinical aspects in neurological critical patients' daily monitoring [PDF]

, 2018
Comment on "Optic Nerve Sheath Diameter Ultrasound Evaluation in Intensive Care Unit: Possible Role and Clinical Aspects in Neurological Critical Patients' Daily Monitoring"
Di Piero, V, Mecarelli, O, Pulitano, P, Rocco, M, Spadetta, G, Toscano, M, Vicenzini, E   +6 more
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Caregiver Engagement in Religious Urban Elementary Schools [PDF]

, 2008
This article examines how school leaders in a religious school serving traditionally marginalized students improve their school communities through constructing space for caregiver engagement.
Scanlan, Martin
core   +1 more source

A Critical Appraisal of Guidelines for Antenatal Care: Components of Care and Priorities in Prenatal Education [PDF]

, 2009
There are a variety of published prenatal care (PNC) guidelines that claim a scientific basis for the information included. Four sets of PNC guidelines published between 2005 and 2009 were examined and critiqued.
Amanda Forristal, American Academy of Pediatrics and the American College of Obstetricians and Gynecologists., Armstrong TM, Declercq ER, Declerq ER, Joyce Roberts, Kirkham C, Kirkham C, Knowles MS., Leona VandeVusse, Lisa Hanson, McDorman MF, Neilson JP., Sable MR, Sakala C, Strong TH., United States Department of Health and Human Services Expert Panel on the Content of Prenatal Care.   +16 more
core   +2 more sources

Antimicrobial-associated harm in critical care: a narrative review

Intensive Care Medicine, 2020
The belief that, for the individual patient, the benefit of prompt and continued use of antimicrobials outweighs any potential harm is a significant barrier to improved stewardship of these vital agents.
N. Arulkumaran, M. Routledge, S. Schlebusch, J. Lipman, A. Conway Morris   +4 more
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source