Results 71 to 80 of about 2,110,747 (304)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Novel Approach to Support Rapid Data Collection, Management, and Visualization During the COVID-19 Outbreak Response in the World Health Organization African Region: Development of a Data Summarization and Visualization Tool

JMIR Public Health and Surveillance, 2020
Background The COVID-19 pandemic has created unprecedented challenges to the systematic and timely sharing of COVID-19 field data collection and management.
Kamran Ahmed, Muhammad Arish Bukhari, Tamayi Mlanda, J. Kimenyi, Polly Wallace, Charles Okot Lukoya, E. Hamblion, B. Impouma   +7 more
semanticscholar   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Adaptive Choropleth Mapper: An Open-Source Web-Based Tool for Synchronous Exploration of Multiple Variables at Multiple Spatial Extents

ISPRS International Journal of Geo-Information, 2019
Choropleth mapping is an essential visualization technique for exploratory spatial data analysis. Visualizing multiple choropleth maps is a technique that spatial analysts use to reveal spatiotemporal patterns of one variable or to compare the ...
Su Yeon Han, Sergio Rey, Elijah Knaap, Wei Kang, Levi Wolf   +4 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Pathview Web: user friendly pathway visualization and data integration

Nucleic Acids Res., 2017
Pathway analysis is widely used in omics studies. Pathway-based data integration and visualization is a critical component of the analysis. To address this need, we recently developed a novel R package called Pathview.
Weijun Luo, G. Pant, Yeshvant K. Bhavnasi, Steven G. Blanchard, Cory R. Brouwer   +4 more
semanticscholar   +1 more source

VIS-Shepherd: Constructing Critic for LLM-based Data Visualization Generation

Data visualization generation using Large Language Models (LLMs) has shown promising results but often produces suboptimal visualizations that require human intervention for improvement. In this work, we introduce VIS-Shepherd, a specialized Multimodal Large Language Model (MLLM)-based critic to evaluate and provide feedback for LLM-generated data ...
Pan, Bo, Fu, Yixiao, Wang, Ke, Lu, Junyu, Pan, Lunke, Qian, Ziyang, Chen, Yuhan, Wang, Guoliang, Zhou, Yitao, Zheng, Li, Tang, Yinghao, Wen, Zhen, Wu, Yuchen, Lu, Junhua, Zhu, Biao, Zhu, Minfeng, Zhang, Bo, Chen, Wei   +17 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Infodemic, Visual Disinformation and Data Literacy. How to Foster Critical Thinking Through the Emerging Data-Graphicacy Competence

, 2023
n an infodemic the citizen must quickly process information, using parameters of thought automation, rather than analytical parameters, and therefore preferring interpretations that employ less cognitive effort and that mainly reflect previous knowledge.
Caccamo A., Cortoni I.
openaire   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source