Results 61 to 70 of about 3,413,512 (272)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Critical behavior of the long-range Ising chain from the largest-cluster probability distribution

, 2000
Monte Carlo simulations of the 1D Ising model with ferromagnetic interactions decaying with distance $r$ as $1/r^{1+\sigma}$ are performed by applying the Swendsen-Wang cluster algorithm with cumulative probabilities.
A. Coniglio, A. Margolina, Ante Aničić, C. M. Fortuin, D. J. Thouless, D. Stauffer, E. Luijten, E. Luijten, E. Luijten, E. Luijten, F. J. Dyson, F. Y. Wu, J. F. Nagle, J. Fröhlich, J. L. Monroe, J. L. Monroe, J. M. Kosterlitz, J. Machta, J. Machta, K. Binder, Katarina Uzelac, M. D’Onorio Meo, M. E. Fisher, M. E. Fisher, M. Kretch, M. Z. Bazant, P. W. Anderson, P. W. Kasteleyn, R. H. Swendsen, S. A. Cannas, U. Wolff, Z. Glumac, Z. Glumac, Z. Glumac, Zvonko Glumac   +34 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Conditions for extreme sensitivity of protein diffusion in membranes to cell environments

, 2006
We study protein diffusion in multicomponent lipid membranes close to a rigid substrate separated by a layer of viscous fluid. The large-distance, long-time asymptotics for Brownian motion are calculated using a nonlinear stochastic Navier-Stokes ...
Baumgart, D. R. Nelson, Hohenberg, Peters, Saffman, Simons, Y. Tserkovnyak   +6 more
core   +2 more sources

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

CRITICAL ASSESSMENT OF OBJECT SEGMENTATION IN AERIAL IMAGE USING GEO-HAUSDORFF DISTANCE [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2016
Aerial Image records the large-range earth objects with the ever-improving spatial and radiometric resolution. It becomes a powerful tool for earth observation, land-coverage survey, geographical census, etc., and helps delineating the boundary of ...
H. Sun, Y. Ding, Y. Huang, G. Wang
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Metric Distance Ranking Technique for Fuzzy Critical Path Analysis

Journal of Applied Sciences and Environmental Management, 2015
In this paper, fuzzy critical path analysis of a project network is carried out. Metric distance ranking technique is used to order fuzzy numbers during the forward and backward pass computations to obtain the earliest start, earliest finish, latest ...
MH Oladeinde, CA Oladeinde
doaj   +1 more source

Distance teaching and teaching ‘as’ distance. A critical reading of online teaching instruments during and after the pandemic

Teoría de la Educación: Revista Interuniversitaria, 2020
This paper intends to read through a critical lens the digitalization of schooling caused by the COVID-19 epidemic. The emergency has forced European governments to close the schools and consequently, all the schooling activities have been transferred ...
Annachiara Gobbi, Federico Rovea
doaj   +1 more source