Results 91 to 100 of about 397,795 (293)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Classification, identification and monitoring methods for static-dynamic stress hazard sources of rock burst in coal mine

Meitan kexue jishu
The prevention and control of rock burst in coal mines should begin from the source, where classification identification and monitoring of static-dynamic stress hazard sources are essential prerequisites for rock burst source control. Based on the theory
Linming DOU, Zhenyu SUN, Anye CAO, Zonglong MU, Siyuan GONG, Wu CAI, Zhifeng MA, Jiazhuo LI, Kunyou ZHOU   +8 more
doaj   +1 more source

Characterizing the Role of Biologically Relevant Fluid Dynamics on Silver Nanoparticle Dependent Oxidative Stress in Adherent and Suspension In Vitro Models

, 2021
Silver nanoparticles (AgNPs) are being employed in numerous consumer goods and applications; however, they are renowned for inducing negative cellular consequences including toxicity, oxidative stress, and an inflammatory response.
Madison F. Bourbon, Kristen A. Krupa, Katherine E. Burns, Maggie E. Jewett, Robert F. Uhrig   +4 more
core   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Experimental study on pressure, stress state, and temperature-dependent dynamic behavior of shear thickening fluid subjected to laser induced shock

, 2015
The dynamic response of the 57 vol./vol. % dense spherical silica particle-polyethylene glycol suspension at high pressure was investigated through short pulsed laser induced shock experiments by measuring the back free surface velocities of aluminum ...
Yin QY, 黄晨光, Wu, XQ (reprint author), Chinese Acad Sci, Inst Mech, Key Lab Mech Fluid Solid Coupling Syst, Beijing 100190, Peoples R China., 吴先前   +3 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Determination of flow stress and the critical strain for the onset of dynamic recrystallization using a hyperbolic tangent function

, 2014
A new model has been developed to estimate the flow stress under hot deformation conditions up to the peak of the stress-strain curves. This model is derived from the general form of hyperbolic function by introducing an additional parameter to bring the
Solhjoo, Soheil, Solhjoo, Soheil; id_orcid   +1 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Dynamic Recrystallization of Elevated Temperature Deforming Austenite of Cu-P-Cr-Ni-Mo Weathering Steel

Teshugang, 2010
The dynamic recrystallization behavior of Cu-P-Cr-Ni-Mo weathering steel (% ： 0. 10C, 0. 075P, 0. 65Cr, 0. 22Ni, 0.43Mo, 0. 28Cu) with strain rate 0. 01 ~ 1 s ~1 at 850 — 1 150 T： has been studied by Gleeble-3500 thermal simulation test machine to get ...
张春玲, 孙睿璇, 蔡大勇, 廖波
doaj  

Hot Compressive Deformation and Processing Maps of ZK60 and ZK60-1.0Er Magnesium Alloy

Cailiao gongcheng, 2017
The hot compressive deformation behavior of ZK60 and ZK60-1.0Er magnesium alloy occurring homogenization was investigated by Gleeble-1500D thermal simulator, analyzing the characteristics of the flow stress changes of the two kinds of magnesium alloys at
WANG Zhong-jun, FU Xue-dan, ZHU Jing, ZHOU Le, WANG Hong-bin   +4 more
doaj   +1 more source