Results 111 to 120 of about 397,795 (293)

Vehicle-bridge dynamic interaction using finite element modelling

, 2010
First investigations on the dynamic response of bridges due to moving loads were motivated by the collapse of the Chester railway bridge in the UK in the middle of the 19th century.
Arturo Gonzalez, González, Arturo
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Dynamic failure analysis and support optimization for web pillars under static and dynamic loading using catastrophe theory

International Journal of Mining Science and Technology
Web pillars enduring complex coupled loads are critical for stability in high-wall mining. This study develops a dynamic failure criterion for web pillars under non-uniform loading using catastrophe theory.
Juyu Jiang, Yulong Zhang, Laigui Wang, Changbo Du, Jun Xu   +4 more
doaj   +1 more source

Norwegian Police Use of Firearms: Critical Decision-Making in Stressful and Dynamic Contexts

, 2020
This is the first study of police decision-making regarding the use of firearms in the Norwegian context; its purpose is to study how police emergency response officers make decisions on the use of firearms, and to understand the contextual factors underlying these decisions.
Henriksen, Steinar Vee, Kruke, Bjørn Ivar   +1 more
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Impact of intensive insulin therapy on dynamic cardiac function in critically ill patients with stress-induced hyperglycemia

World Journal of Diabetes
BACKGROUND Stress-induced hyperglycemia (SIH) is common in critically ill patients and has been associated with adverse cardiovascular outcomes. Intensive insulin therapy (IIT) has been proposed to mitigate these risks by achieving tighter glycemic control. AIM To evaluate the efficacy of IIT for managing SIH in critically
Wang, Yu-Dan, Yu, Jing-Jing
openaire   +2 more sources

Effects of principal stress rotation and drainage on the resilient stiffness of railway foundations

, 2013
Railway foundations play an integral role in controlling the stability of the overlying track structure and the maintenance of the overall track geometry.
Mamou, A.
core  

Dynamic Stress Analysis of Engine Shafts in Automobile Industries

, 2019
In the present work, stress analysis of engine shafts in an Automobile industry has been carried out. The dynamic analysis is performed on the engine shaft to determine stress and deformation that developed across its length when subjected to variable ...
Kumar Karri, Mr. Venkata Sanyasi Seshendra, Venkata Sanyasi Seshendra Kumar Karri   +1 more
core   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source