Results 91 to 100 of about 12,861,561 (372)
On the approach to the critical solution in leading order thin-film coating and rimming flow [PDF]
, 2009 The approach to the critical solution in leading order coating and rimming flow of a thin fluid film on a uniformly rotating horizontal cylinder is investigated.
Ashmore +18 more
core +1 more source
FEBS Letters, EarlyView.Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria +3 more
wiley +1 more source
Nature Communications, 2020 Bioorthogonal non-canonical amino acid tagging (BONCAT) coupled with flow cytometry (FACS) has been utilized to profile active microbiome of environmental samples.
Talia D. Valentini +6 more
doaj +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
FEBS Letters, EarlyView.Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield +3 more
wiley +1 more source
Improving parallel program performance using critical path analysis [PDF]
, 1989 A programming tool that performs analysis of critical paths for parallel programs has been developed. This tool determines the critical path for the program as scheduled onto a parallel computer with P processing elements, the critical path for the ...
Bic, Lubomir +2 more
core
Landau critical velocity in weakly interacting Bose gases
, 2012 The flow of a uniform Bose gas at speeds greater than the Landau critical velocity, v_c, does not necessarily destroy superfluidity, but rather need only lead to a decrease of the superfluid mass density, {\rho}_s. Analyzing a weakly interacting Bose gas
C. J. Pethick +4 more
core +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
The Critical Conditions of Filtration Flow Blocking in a Porous Channel with Phase Transitions [PDF]
Journal of Heat and Mass Transfer ResearchThe paper studies the occurrence of kinetic phase transitions in porous media with thermodynamic phase transitions, which affect filtration flow through permeability or viscosity: in the simplest case, permeability is a step function of local temperature.
Igor Donskoy
doaj +1 more source