Results 91 to 100 of about 4,165,741 (291)

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta   +6 more
wiley   +1 more source

The Critical Conditions of Filtration Flow Blocking in a Porous Channel with Phase Transitions [PDF]

open access: yesJournal of Heat and Mass Transfer Research
The paper studies the occurrence of kinetic phase transitions in porous media with thermodynamic phase transitions, which affect filtration flow through permeability or viscosity: in the simplest case, permeability is a step function of local temperature.
Igor Donskoy
doaj   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi   +5 more
wiley   +1 more source

Sparsity of 3-flow-critical graphs

open access: yesEuropean Journal of Combinatorics
A connected graph G is 3-flow-critical if G does not have a nowhere-zero 3-flow, but every proper contraction of G does. We prove that every n-vertex 3-flow-critical graph other than K_2 and K_4 has at least 5n/3 edges. This bound is tight up to lower-order terms, answering a question of Li et al. (2022). It also generalizes the result of Koester (1991)
Zdenek Dvorák 0001, Sergey Norin
openaire   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

RELACIÓN DE LAS CURVAS DE ENERGÍA ESPECÍFICA Y PENDIENTE DE FRICCIÓN CON LAS ZONAS DE FLUJO LIBRE EN CANALES

open access: yesRevista EIA, 2008
Uno de los objetivos de un curso básico de hidráulica del flujo libre en canales es el análisis de perfiles del flujo gradualmente variado. Este trabajo proporciona una estrategia de enseñanza-aprendizaje que puede mejorar la práctica universitaria ...
Francisco Jaime Mejía
doaj  

Flow patterns and critical criteria of thermally stratified shear flow in braided rivers

open access: yesWater Science and Engineering, 2017
Flow characteristics of thermally stratified shear flow in braided rivers are particularly complicated and poorly understood. In this study, a series of typical flow patterns was examined and their critical criteria were determined.
Li Gu   +5 more
doaj   +1 more source

Entry effects of droplet in a micro confinement: implications for deformation-based CTC microfiltration

open access: yes, 2015
Deformation based circulating tumor cell (CTC) microchips are a representative diagnostic device for early cancer detection. This type of device usually involves a process of CTC trapping in a confined microgeometry. Further understanding of the CTC flow
Chen, Xiaolin, Xu, Jie, Zhang, Zhifeng
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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