Results 161 to 170 of about 12,929,549 (289)

Effects of perfusion-guided permissive hypotension and early vasopressin initiation in adults with septic shock: protocol for a multicentre 2×2 factorial randomised controlled trial in Japanese intensive care units. [PDF]

BMJ Open
Endo A, Yamakawa K, Tagami T, Yamamoto R, Umemura Y, Takayama W, Hoshi H, Hayashi Y, Komori A, Yanagisawa T, Hisamune R, Yoshino Y, Murao S, Okubo S, Azumaguchi R, Narita C, Ono T, Masaki T, Shoko T, Yamagiwa T, Takahashi J, Suekane A, Oi Y, Matsuura H, Miura N, Koami H, Kimoto K, Oishi T, Takahashi K, Wada T.   +29 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Multiple solutions for semilinear Robin problems with superlinear reaction and no symmetries

Electronic Journal of Differential Equations, 2021
Nikolaos S. Papageorgiou, Calogero Vetro, Francesca Vetro   +2 more
doaj  

Evaluation of the Osteoconductive Capacity of Micro-Hydroxyapatite and Nano-Hydroxyapatite Associated with Beta-Tricalcium Phosphate: Experimental Study in Critical Calvarial Defects in Rats. [PDF]

J Funct Biomater
Alves MEG, Brum IDS, Sol I, Gonçalves MEA, Lopes JPS, Elias CN, Frigo L, Nascimento ALR, Carvalho JJ, Ponzoni D.   +9 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. [PDF]

J Vet Emerg Crit Care (San Antonio)
Conti-Patara A, Martin LG.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

An Evaluation of ICU Follow-Up Clinic Attendance and Subsequent Healthcare Resource Utilization in Wales, United Kingdom: A Retrospective, Population-Level Data-Linkage Study. [PDF]

Crit Care Explor
McGinn LM, Twose P, Pugh RJ, Bedston S, Bailey R, Szakmany T.   +5 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source