Results 141 to 150 of about 2,853,090 (311)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Cyclic Critical Groups of Graphs

, 2016
In this note, we describe a construction that leads to families of graphs whose critical groups are cyclic. For some of these families we are able to give a formula for the number of spanning trees of the graph, which then determines the group ...
Glass, Darren B., Becker, Ryan P.
core  

Updating the distribution of the genus Callitriche (Plantaginaceae) in Italy from the study of the Herbarium Centrale Italicum collections

Mediterranean Botany
The first results of a herbariological study on the genus Callitriche L. at the Central Italian Herbarium (Herbarium Centrale Italicum) of the Museum of Natural History of the University of Florence are presented.
Lorenzo Lastrucci, Daniele Saiani, Alessio Mugnai, Giulio Ferretti, Daniele Viciani   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Multiplicity results for non-local operators of elliptic type

Results in Applied Mathematics
In this paper, we study a class of problems proposed by Servadei and Valdinoci (2013); namely, (1) −LKu(x)−λu(x)=f(x,u),forx∈Ω;u=0inRN∖Ω,where Ω⊂RN is an open bounded set with Lipschitz boundary, λ∈R, f∈C1(Ω¯×R,R), with f(x,0)=0 for x∈Ω, and LK is a non ...
Emer Lopera, Leandro Recôva, Adolfo Rumbos   +2 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The critical number of finite abelian groups

, 2009
Let G be an additive, finite abelian group. The critical number cr(G) of G is the smallest positive integer ℓ such that for every subset S⊂G∖{0} with |S|⩾ℓ the following holds: Every element of G can be written as a nonempty sum of distinct elements from
Freeze, Michael, Gao, Weidong, Geroldinger, Alfred   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Multicultural food events – opportunities for intercultural exchange and risks of stereotypification

Events based on food from various cultures are often promoted as multicultural and as opportunities for establishing insights into other cultures. They are also highlighted as springboards for recently immigrated food entrepreneurs and as spaces for ...
Kraff, Helena,, Jernsand, Eva Maria,
core   +1 more source

A weighted (p,2)-equation with double resonance

Electronic Journal of Differential Equations, 2023
Zhenhai Liu, Nikolaos S. Papageorgiou
doaj