Results 91 to 100 of about 6,560,806 (389)

Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome

Frontiers in Immunology, 2018
Dysregulated host immune responses to infection often occur, leading to sepsis, multiple organ failure, and death. Some patients rapidly recover from sepsis, but many develop chronic critical illness (CCI), a debilitating condition that impacts ...
Russell B. Hawkins, Steven L. Raymond, Julie A. Stortz, Hiroyuki Horiguchi, Scott C. Brakenridge, Anna Gardner, Philip A. Efron, Azra Bihorac, Azra Bihorac, Mark Segal, Mark Segal, Frederick A. Moore, Lyle L. Moldawer   +12 more
doaj   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness [PDF]

, 2018
BACKGROUND: There are conflicting data on the effects of antipsychotic medications on delirium in patients in the intensive care unit (ICU). METHODS: In a randomized, double-blind, placebo-controlled trial, we assigned patients with acute ...
Bernard, G.R., Boehm, L.M., Bowton, D.L., Brummel, N.E., Carson, S.S., Chandrasekhar, R., Dittus, R.S., Douglas, I.S., Ely, E.W., Exline, M.C., Feinstein, D.J., Girard, T.D., Gong, M.N., Hite, R.D., Hough, C.L., Hughes, C.G., Hyzy, R.C., Jackson, J.C., Khan, B., Malhotra, A., Masica, A.L., Owens, R.L., Pandharipande, P.P., Patel, M.B., Pisani, M.A., Pun, B.T., Rock, P., Schmidt, G.A., Schweickert, W.D., Stollings, J.L., Strength, C., Thompson, J.L.   +31 more
core   +1 more source

Evaluating physical functioning in critical care: considerations for clinical practice and research

Critical Care, 2017
The evaluation of physical functioning is valuable in the intensive care unit (ICU) to help inform patient recovery after critical illness, to identify patients who may require rehabilitation interventions, and to monitor responsiveness to such ...
Selina M. Parry, Minxuan Huang, Dale M. Needham   +2 more
doaj   +1 more source

Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia, Stephane Rodriguez, Emilie Dugast, Christine Lebrun‐Frenay, Eric Thouvenot, Jérôme de Sèze, Emmanuelle Le Page, Sandra Vukusic, Inès Doghri, Eric Berger, Olivier Casez, Pierre Labauge, Aurélie Ruet, Catarina Raposo, Fabienne Le Frère, Arnaud B. Nicot, Sandrine Wiertlewski, Pierre‐Antoine Gourraud, Laure Michel, Laureline Berthelot, David‐Axel Laplaud   +20 more
wiley   +1 more source

Leukocyte telomere length in paediatric critical illness [PDF]

, 2018
__Background:__ Children who have suffered from critical illnesses that required treatment in a paediatric intensive care unit (PICU) have long-term physical and neurodevelopmental impairments. The mechanisms underlying this legacy remain largely unknown.
C. Ingels (Catherine), Derese, I. (Inge), Guerra, G.G. (Gonzalo Garcia), Hanot, J. (Jan), J. Lin (Jue), Joosten, K.F.M. (Koen), Puffelen, E. (Esther) van, Van den Berghe, G. (Greet), Vanhorebeek, I. (Ilse), Verbruggen, S.C.A.T. (Sascha), Verstraete, S. (Sören), Vlasselaers, D. (Dirk), Wouters, P.J. (Pieter)   +12 more
core   +1 more source

ICU‐EEG Pattern Detection by a Convolutional Neural Network

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients in the intensive care unit (ICU) often require continuous EEG (cEEG) monitoring due to the high risk of seizures and rhythmic and periodic patterns (RPPs). However, interpreting cEEG in real time is resource‐intensive and heavily relies on specialized expertise, which is not always available.
Giulio Degano, Hervé Quintard, Andreas Kleinschmidt, Nikita Francini, Oana E. Sarbu, Pia De Stefano   +5 more
wiley   +1 more source

Statin therapy in critical illness : an international survey of intensive care physicians' opinions, attitudes and practice [PDF]

, 2012
Background Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ failure.
Di Gangi, Stefania, Kruger, Peter S., McAuley, Danny F., Perkins, Gavin D., Scales, Damon C., Shankar-Hari, Manu, Terblanche, Marius   +6 more
core   +1 more source

Prevalence and Course of Frailty in Survivors of Critical Illness*

Critical Care Medicine, 2020
Supplemental Digital Content is available in the text. Objectives: Little is known about frailty that develops following critical illness. We sought to describe the prevalence of newly acquired frailty, its clinical course, and the co-occurrence of ...
N. Brummel, T. Girard, P. Pandharipande, Jennifer L. Thompson, Ryan T. Jarrett, R. Raman, C. Hughes, Mayur B. Patel, A. Morandi, T. Gill, E. W. Ely   +10 more
semanticscholar   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source