Results 71 to 80 of about 1,378,904 (356)

Cognitive and physical exercise to improve outcomes after surgery (COPE-iOS) study: protocol for a randomised, controlled trial in the USA examining the efficacy of a combined cognitive and physical exercise programme performed before and after major surgery in improving cognitive and functional outcomes for older adults

BMJ Open
Introduction Surgery and its resulting hospitalisation are associated with subsequent cognitive and functional decline. Interventions to reduce this decline have exhibited limited success.
Pratik P Pandharipande, Christopher G Hughes, Kimberly F Rengel, Kristin R Archer, Jim C Jackson, Rameela Raman, Onur M Orun, Terri Ellison, Susan W Vanston, Hope Ervin, Alana Lauck, Madison Provin   +11 more
doaj   +1 more source

Implementing nudges to promote utilization of low tidal volume ventilation (INPUT): a stepped-wedge, hybrid type III trial of strategies to improve evidence-based mechanical ventilation management

Implementation Science, 2021
Background Behavioral economic insights have yielded strategies to overcome implementation barriers. For example, default strategies and accountable justification strategies have improved adherence to best practices in clinical settings.
Meeta Prasad Kerlin, Dylan Small, Barry D. Fuchs, Mark E. Mikkelsen, Wei Wang, Teresa Tran, Stefania Scott, Aerielle Belk, Jasmine A. Silvestri, Tamar Klaiman, Scott D. Halpern, Rinad S. Beidas   +11 more
doaj   +1 more source

Risk factors in critical illness myopathy during the early course of critical illness: a prospective observational study [PDF]

, 2010
INTRODUCTION: Non-excitable muscle membrane indicates critical illness myopathy (CIM) during early critical illness. We investigated predisposing risk factors for non-excitable muscle membrane at onset of critical illness.
Claudia D Spies, Didier Keh, Florian Bubser, Joachim Spranger, Klaus D Wernecke, Maria Deja, Simone Spuler, Steffen Weber-Carstens, Susanne Koch   +8 more
core   +3 more sources

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Long-term psychosocial impact reported by childhood critical illness survivors: a systematic review [PDF]

, 2013
Aim: To undertake a qualitative systematic review that explores psychological and social impact, reported directly from children and adolescents at least 6 months after their critical illness.
Atkins, Bailey, Bury, Centre for Reviews and Dissemination, Charmaz, Colville, Cutler, Nelson, Noyes, Odetola, Petticrew, PICANet, Rennick, Shudy, Skrobik, Stein-Parbury, Taylor, Thomas, Thomas, Truman, Wallace, Walsh, Walsh   +22 more
core   +3 more sources

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome

Frontiers in Immunology, 2018
Dysregulated host immune responses to infection often occur, leading to sepsis, multiple organ failure, and death. Some patients rapidly recover from sepsis, but many develop chronic critical illness (CCI), a debilitating condition that impacts ...
Russell B. Hawkins, Steven L. Raymond, Julie A. Stortz, Hiroyuki Horiguchi, Scott C. Brakenridge, Anna Gardner, Philip A. Efron, Azra Bihorac, Azra Bihorac, Mark Segal, Mark Segal, Frederick A. Moore, Lyle L. Moldawer   +12 more
doaj   +1 more source

2010 Annual Evidence Update on Critical Illness Rehabilitation [PDF]

, 2010
For this annual evidence update a detailed literature review was undertaken to retrieve any evidence published subsequent to the literature search which formed the basis for the NICE guideline.
Gibson, Vanessa, Griffiths, John, Kishen, Roop, Morris, Craig, Parker, Robert, Treacher, David   +5 more
core  

Levosimendan in critical illness: A literature review [PDF]

, 2014
Levosimendan, the active enantiomer of simendan, is a calcium sensitizer developed for treatment of decompensated heart failure, exerts its effects independently of the beta adrenergic receptor and seems beneficial in cases of severe, intractable heart ...
Franchi, Federico, Karanikolas, Menelaos, Muzzi, Luigi, Pierrakos, Charalampos, Scolletta, Sabino, Velissaris, Dimitrios   +5 more
core   +2 more sources

Prognostic Implications of Sleep Architecture for Patients Admitted to the Intensive Care Unit With Status Epilepticus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu, Marcus C. Ng, Gavin P. Winston, Sabrina Schaly, Garima Shukla, Lysa Boissé Lomax   +5 more
wiley   +1 more source