Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Surviving physiological stress: Can insights into human adaptation to austere environments be applied to the critical care unit? [PDF]
, 2016 The harshest environment that many people will ever face is the critical care unit, where pathology can stress homeostatic mechanisms beyond their limits, leading to multiple organ failure and death.
Martin, D, McKenna, H
core +1 more source
Opioid Tolerance in Critical Illness
New England Journal of Medicine, 2019 Opioid Tolerance in Critical Illness This review describes the indications for opioid therapy in patients in the intensive care unit, mechanisms of opioid tolerance, and current and potential mitig...
J. Martyn, J. Mao, E. Bittner
semanticscholar +1 more source
Critical illness related cardiac arrest: Protocol for an investigation of the incidence and outcome of cardiac arrest within intensive care units in the United Kingdom [PDF]
, 2022 Robert Darnell +8 more
openalex +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Status epilepticus (SE) is associated with significant mortality. Sleep architecture may reflect normal brain function. Impaired sleep architecture is associated with poorer outcomes in numerous conditions. Here we investigate the association of sleep architecture in continuous EEG (cEEG) with survival in SE.
Ran R. Liu +5 more
wiley +1 more source
The Pan African Medical Journal, 2018 INTRODUCTION: in critically ill patients, there is a defect in host defense mechanism resulting in increased susceptibility to bacterial and fungal infection.
Gurmeet Singh, Stephanie Gita Wulansari
doaj +1 more source
Critical Care Medicine, 2019 Objectives: This study sought to examine mortality, health-related quality of life, and physical function among sepsis survivors who developed chronic critical illness.
Anna K. Gardner +11 more
semanticscholar +1 more source
Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley +1 more source
A systematic review of reviews of interventions to promote mental health and prevent mental health problems in children and young people [PDF]
, 2007 Background: There is a growing policy imperative to promote positive mental health as well as preventing the development of mental health problems in children.
Barlow, Jane +4 more
core +1 more source
A case report of classic galactosemia with a GALT gene variant and a literature review
BMC PediatricsBackground Galactosemia is an autosomal recessive disorder resulting from an enzyme defect in the galactose metabolic pathway. The most severe manifestation of classic galactosemia is caused by galactose-1-phosphate uridylyltransferase (GALT) deficiency,
Yong-cai Wang +5 more
doaj +1 more source