Results 241 to 250 of about 1,378,904 (356)

Trends in Discharge to Hospice After Critical Illness Among US Medicare Beneficiaries, 2011-2023. [PDF]

Ann Am Thorac Soc
Law AC, Bosch NA, Song Y, Tale AP, Nelson J, Wadhera RK, Barnato AE, Walkey AJ.   +7 more
europepmc   +1 more source

The therapeutic targets and signaling mechanisms of ondansetron in the treatment of critical illness in the ICU [PDF]

Lili Tao, Zhenhui Zhang, Chuang Li, Minxuan Huang, Ping Chang   +4 more
openalex   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Days Alive and at Home After Critical Illness Hospitalization Among Older Adults and Its Association With Delivery of In-Hospital Rehabilitation. [PDF]

Crit Care Med
Kim S, Murphy TE, O'Leary JR, Leo-Summers L, Falvey JR, Gill TM, Krumholz HM, Ferrante LE, Jain S, Jain S.   +9 more
europepmc   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Targeting and monitoring mean arterial pressure in critical illness: A mixed-methods service evaluation. [PDF]

J Intensive Care Soc
MacKay I, Piper I, Docherty AB.
europepmc   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Immune signatures of sepsis from mild infection to critical illness - a prospective observational study. [PDF]

Front Immunol
Snow TAC, Ryckaert F, Hass I, Pan H, Elkhodair S, Singer M, Brealey D, Arulkumaran N, University College London Hospitals Critical Care Research Team.   +8 more
europepmc   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

The mental health effects of critical illness insurance: Evidence from China's aging population. [PDF]

PLoS One
Zhang Y, Tian M, Zhang Y, Zang W.
europepmc   +1 more source