Results 81 to 90 of about 5,699,579 (389)

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID-19

open access: yesCritical Care, 2020
Background COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus.
J. Bermejo-Martín   +65 more
semanticscholar   +1 more source

Reinforcement Learning For Survival, A Clinically Motivated Method For Critically Ill Patients [PDF]

open access: yesarXiv, 2022
There has been considerable interest in leveraging RL and stochastic control methods to learn optimal treatment strategies for critically ill patients, directly from observational data. However, there is significant ambiguity on the control objective and on the best reward choice for the standard RL objective.
arxiv  

Association of Hypoactive and Hyperactive Delirium With Cognitive Function After Critical Illness

open access: yesCritical Care Medicine, 2020
Supplemental Digital Content is available in the text. Objectives: Delirium, a heterogenous syndrome, is associated with worse long-term cognition after critical illness.
C. Hayhurst   +13 more
semanticscholar   +1 more source

COVID-19 Associated Pulmonary Aspergillosis: A Case Series

open access: yesActa Medica Indonesiana, 2022
Coronavirus disease 2019 (COVID-19) has been a worldwide pandemic with several problems, one of which is the lack of definitive treatment. COVID-19-associated pulmonary aspergillosis (CAPA), the presence of invasive pulmonary aspergillosis (IPA) in COVID-
Mira Yulianti   +5 more
doaj  

On the ill-posedness of the compressible Navier-Stokes equations in the critical Besov spaces [PDF]

open access: yesRevista Matematica Iberoamericana, 31 (2015), no. 4, 1375--1402, 2011
We prove the ill-posedness of the 3-D baratropic Navier-Stokes equation for the initial density and velocity belonging to the critical Besov space $(\dot{B}^{\f 3p}_{p,1}+\bar{\rho},\,\dot{B}^{\f 3p-1}_{p,1})$ for $p>6$ in the sense that a ``norm inflation" happens in finite time, here $\bar{\rho}$ is a positive constant.
arxiv   +1 more source

Prevalence of and Recovery From Anemia Following Hospitalization for Critical Illness Among Adults

open access: yesJAMA Network Open, 2020
Key Points Question Is anemia in patients with critical illness associated with persistent anemia following discharge? Findings In this cohort study of 6901 adults hospitalized for critical illness, 41% had prevalent anemia preceding hospitalization and ...
M. Warner   +6 more
semanticscholar   +1 more source

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

open access: yesMolecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang   +8 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

open access: yesFEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel   +3 more
wiley   +1 more source

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