Results 121 to 130 of about 129,036 (402)

Is amputation in the elderly patient with critical limb ischemia acceptable in the long term?

Clinical Interventions in Aging, 2019
Chloé ML Peters,1 Jolanda de Vries,2,3 Eelco J Veen,1 Hans GW de Groot,1 Gwan H Ho,1 Paul Lodder,2,4 Stijn L Steunenberg,1 Lijckle van der Laan11Department of Surgery, Amphia Hospital, Breda, The Netherlands; 2Department of Medical and ...
Peters CML, de Vries J, Veen EJ, de Groot HGW, Ho GH, Lodder P, Steunenberg SL, van der Laan L   +7 more
doaj  

Investigation of Lower-limb Tissue Perfusion during Loading [PDF]

, 2002
An extant tissue indentor used for amputee residual limb tissue indentation studies was modified to include laser Doppler flowmetry (LDF) to enable measurement of tissue perfusion during indentation.
Silver-Thorn, Barbara
core   +1 more source

Controlled Delivery of Sdf-1 Alpha and Igf-1: Cxcr4(+) Cell Recruitment and Functional Skeletal Muscle Recovery [PDF]

, 2015
Therapeutic delivery of regeneration-promoting biological factors directly to the site of injury has demonstrated its efficacy in various injury models.
Farrar, Roger P., Hammers, David W., Hsieh, Pei-Ling, Merscham-Banda, Melissa, Pham, Chantal B., Rybalko, Viktoriya Y., Suggs, Laura J.   +6 more
core   +1 more source

Long-Term Outcomes of BMMSC Compared with BMMNC for Treatment of Critical Limb Ischemia and Foot Ulcer in Patients with Diabetes

Cell Transplantation, 2019
We first compared long-term clinical outcomes in treating critical limb ischemia (CLI) and foot ulcer in patients with diabetes between autologous bone marrow mesenchymal stem cell (BMMSC) and bone-marrow-derived mononuclear cell (BMMNC) transplants ...
De-bin Lu, You-zhao Jiang, Wuquan Deng, Yan Zhang, Z. Liang, Qinan Wu, Xiaoyan Jiang, Ling Zhang, F. Gao, Yin Cao, Bing Chen, Yao-ming Xue   +11 more
semanticscholar   +1 more source

Regenerative Medicine in Critical Limb Ischemia

Journal of Atherosclerosis and Thrombosis, 2012
Critical limb ischemia (CLI) is commonly caused by atherosclerotic arterial obstruction or stenosis in the leg, as demonstrated by rest pain, skin ulcers and gangrene (Fontaine III or IV), often fails to respond to conservative treatments, and carries a high risk for limb amputation, with a particularly dismal prognosis.
Masanori Fukushima, Yoji Nagai, Takayuki Ohno, Hideaki Kaneda   +3 more
openaire   +3 more sources

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

Critical limb ischemia: an update for interventional radiologists

Diagnostic and Interventional Radiology, 2013
Critical limb ischemia (CLI) is a growing epidemic with bleak patient outcomes. A variety of treatment modalities have been adopted to address CLI based on comorbidities, life expectancy, and the nature of the arterial disease.
Nicholas F. Brazeau,, Erique G. Pinto,, Harlan B. Harvey,, George R. Oliveira,, Benjamin J. Pomerantz,, Stephan Wicky,, Rahmi Oklu   +6 more
doaj   +1 more source

Myocardial revascularization in diabetic patients presenting with critical limbischemia

Сахарный диабет, 2010
The frequency of diabetic complications remains high despite the development of improved therapeutic modalities. Macroangiopathy continues to bethe predominant complication while coronary heart disease is the main cause of mortality.This paper considers ...
Ivan Ivanovich Dedov, Victor Yur'evich Kalashnikov, Konstantin Vladimirovich Melkozerov   +2 more
doaj   +1 more source

Accuracy of SVS-WIfI Classification in Predicting Major Amputation in Critical Limb Ischemic Patients

Majalah Kedokteran Bandung, 2020
In 2014, The Society for Vascular Surgery revealed a new classification system for Critical Limb Ischemia (CLI) referred as the Society for Vascular Surgery Lower Extremity Threatened Limb Classification System based on Wound, Ischemia, and foot ...
Teguh Marfen Djajakusumah, Rani Septrina, Putie Hapsari, Rendy Susanto   +3 more
doaj   +1 more source

Cell-free Embryonic Stem Cell Extract-mediated Derivation of Multi-potent Stem Cells from NIH3T3 Fibroblasts for Functional and Anatomical Ischemic Tissue Repair [PDF]

, 2007
The oocyte-independent generation of multipotent stem cells is one of the goals in regenerative medicine. We report that upon exposure to mouse ES cell (ESC) extracts, reversibly permeabilized NIH3T3 cells undergo de-differentiation followed by stimulus ...
Deepali Ahluwalia, Douglas W. Losordo, Erin Lambers, Evelyn Bord, Gangjian Qin, Hiromichi Hamada, Ilona Goukassian, Johnson Rajasingh, Karen Schlauch, Kenneth M. Rosen, Prasanna Krishnamurthy, Raj Kishore, Tina Thorne, Yan Zhu   +13 more
core   +1 more source