Results 91 to 100 of about 6,591,243 (297)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Collapsing lattice animals and lattice trees in two dimensions

, 2005
We present high statistics simulations of weighted lattice bond animals and lattice trees on the square lattice, with fugacities for each non-bonded contact and for each bond between two neighbouring monomers.
Borstnik B, de Gennes P G, Derrida B, Dickman R, Flesia S, Flesia S, Grassberger P, Grassberger P, Grosberg A Yu, Hsiao-Ping Hsu, Hsu H P, Hsu H-P, Janse van Rensburg E J, Janse van Rensburg E J, Janse van Rensburg E J, Lubensky T C, Madras N, Nienhuis B, Peard P, Peter Grassberger, Seno F, Seno F, Stauffer D, Stratychuk L M   +23 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Regarding Physical and Chemical Transformations with the Involvement of Water Near –45 °C

Конденсированные среды и межфазные границы, 2019
Objective. A hypothesis about a new mechanism for accelerating chemical reactions involving supercooled water near -45 °С is presented. The hypothesis is based on the properties of the second critical point of water at a temperature of –53 °C and a ...
Georgy S. Bordonsky, Alexander A. Gurulev   +1 more
doaj   +1 more source

Adjoint Wilson Line in SU(2) Lattice Gauge Theory

, 1993
The behavior of the adjoint Wilson line in finite-temperature, $SU(2)$, lattice gauge theory is discussed. The expectation value of the line and the associated excess free energy reveal the response of the finite-temperature gauge field to the presence ...
A. Chodos, A. Chodos, A. Patel, B. Svetitsky, B. Svetitsky, F. Takagi, J. Engels, J. Engels, J. Engels, J. Fingberg, J. Fingberg, J. Kiskis, J. Kiskis, J. Kiskis, J. Kiskis, Joe Kiskis, K. Redlich, K. Redlich, M. Barber, M. Fisher, M. Okawa, P. Damgaard, P. Vranas, P. Vranas, Pavlos Vranas, R. Ben-Av, R. Jaffe, R. Jaffe, T. DeGrand, U. Heller, V. Dotsenko   +30 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Runaway of Line-Driven Winds Towards Critical and Overloaded solutions

, 2000
Line-driven winds from hot stars and accretion disks are thought to adopt a unique, critical solution which corresponds to maximum mass loss rate and a particular velocity law.
Achim Feldmeier, Feldmeier A., Isaac Shlosman   +2 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Field-induced vortex-like textures as a probe of the critical line in reentrant spin glasses. [PDF]

Sci Rep, 2021
Martin N, Bannenberg LJ, Deutsch M, Pappas C, Chaboussant G, Cubitt R, Mirebeau I.   +6 more
europepmc   +1 more source