Results 111 to 120 of about 6,591,243 (297)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Temperature Dependence of the Flux Line Lattice Transition into Square Symmetry in Superconducting LuNi$_2$B$_2$C

, 2001
We have investigated the temperature dependence of the H || c flux line lattice structural phase transition from square to hexagonal symmetry, in the tetragonal superconductor LuNi_2B_2C (T_c = 16.6 K).
A. B. Abrahamsen, A. B. Abrahamsen, B. Rosenstein, D. K. Christen, D. K. Christen, D. McK. Paul, I. Affleck, J. Schelten, K. Mortensen, K. O. Cheon, M. Ichioka, M. R. Eskildsen, M. R. Eskildsen, M. R. Eskildsen, M. R. Eskildsen, M. Yethiraj, M. Yethiraj, N. H. Andersen, P. C. Canfield, P. C. Canfield, P. L. Gammel, P. L. Gammel, U. Klein, U. Yaron, V. G. Kogan, V. G. Kogan, V. G. Kogan, V. G. Kogan, Y. DeWilde, Z. D. Hao   +29 more
core   +2 more sources

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Dynamic analysis and vibration testing of CFRP drive-line system used in heavy-duty machine tool

Results in Physics, 2018
Low critical rotary speed and large vibration in the metal drive-line system of heavy-duty machine tool affect the machining precision seriously. Replacing metal drive-line with the CFRP drive-line can effectively solve this problem.
Mo Yang, Lin Gui, Yefa Hu, Guoping Ding, Chunsheng Song   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Determination of the Critical State Line in Partially Frozen Sand

Geotechnics
A new method for measuring internal pore water pressure (PWP) is introduced to determine the critical state line (CSL) in partially frozen sand, investigating the influence of temperature and strain rate on the critical state parameters.
Yawu Liang, Nicholas Beier, Dave C. Sego
doaj   +1 more source

Development of a Preventive Maintenance Strategy for an Automatic Production Line Based on Group Maintenance Method

Applied Sciences, 2018
The high maintenance costs and low reliability of automatic production line are attributed to the complexity of maintenance management. In the present study, a preventive maintenance strategy for the automatic production line was developed based on the ...
Guofa Li, Yi Li, Xinge Zhang, Chao Hou, Jialong He, Binbin Xu, Jinghao Chen   +6 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source