Results 141 to 150 of about 10,215,756 (277)
, 2023 Currently, Twin Screw Wet Granulation is considered an innovative technology enabling the pharmaceutical industry to transition from its characteristic conventional batch manufacturing to continuous manufacturing. The innovation of this promising manufacturing technology that sets it apart from other granulation types is its capability to integrate ...
openaire +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
, 2010 The Center for Embedded Systems for Critical Applications (CESCA) held its annual workshop titled “CESCA Day” at the Owens Banquet Hall in Blacksburg, Va., on May 6, 2010! Events included keynote, tutorials, poster sessions, and a student panel.
Virginia Tech. Center for Embedded Systems for Critical Applications
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FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
The Multifunctional Attributes of Northeastern Agriculture: A Research Agenda [PDF]
In the United States' Northeastern region, there is an increasing interest in the public benefits from agriculture. These benefits are frequently referred to as multifunctional attributes. The policy challenge is to find an effective way to reflect these
Batie, Sandra S.
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Threonine 348 regulates the subcellular localization of PTEN
FEBS Open Bio, EarlyView.Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley +1 more source
Geometry & Mechanism: Material Metaphors and the Force of Uncertainty in Legal Thought
, 2018 This essay takes up the metaphors through which realists and Critical Legal Studies scholars created an idea of legal formalism. These insistently material metaphors emphasized that the errors of so-called formalist jurisprudence arose from two things ...
Huerta, Monica
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BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells
FEBS Open Bio, EarlyView.BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley +1 more source
EFFECTS OF ADDITIONAL QUALITY ATTRIBUTES ON CONSUMER WILLINGNESS-TO-PAY FOR FOOD LABELS [PDF]
Contingent valuation (CV), choice experiment (CE) and experimental auction (EA) or the combinations of the three methods are often used by researchers to elicit consumer willingness to pay for food attributes (food labels).
Gao, Zhifeng, Schroeder, Ted C.
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FEBS Open Bio, EarlyView.The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen +8 more
wiley +1 more source