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Impact of material attributes & process parameters on critical quality attributes of the amorphous solid dispersion products obtained using hot melt extrusion [PDF]
, 2019 The feasibility of hot melt extrusion (HME) was explored for development of amorphous solid dispersion systems. Controlled release formulations were developed using a cellulose based derivative, AffinisolTMHPMC 100cP and 4M grades. BCS class II drugs ibuprofen and posaconazole were selected due to their difference in glass transition temperature and ...
Sabnis, Aniket D.
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Systemic Practice and Action Research, 2013
Social responsibility (SR) requires critical self-evaluating personalities. Here is a case of self-measurement. Some basic content-, methodology- and implementation-related characteristics of evaluation in education are presented. Particularly emphasized are attributes of good evaluation and good evaluators.
Branka Čagran, Milena Ivanuš Grmek
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Social responsibility (SR) requires critical self-evaluating personalities. Here is a case of self-measurement. Some basic content-, methodology- and implementation-related characteristics of evaluation in education are presented. Particularly emphasized are attributes of good evaluation and good evaluators.
Branka Čagran, Milena Ivanuš Grmek
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Journal of the Science of Food and Agriculture, 2017
AbstractBACKGROUNDHigh levels of aspalathin, an antidiabetic dihydrochalcone, in green rooibos underpins interest in the production of a standardised extract. Elements of a quality‐by‐design approach were applied to optimise extraction conditions, aiming at the delivery of a dry matter yield (DMY) ≥ 160 g kg−1 and an extract with an aspalathin content (
Neil Miller +2 more
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AbstractBACKGROUNDHigh levels of aspalathin, an antidiabetic dihydrochalcone, in green rooibos underpins interest in the production of a standardised extract. Elements of a quality‐by‐design approach were applied to optimise extraction conditions, aiming at the delivery of a dry matter yield (DMY) ≥ 160 g kg−1 and an extract with an aspalathin content (
Neil Miller +2 more
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International Journal of Pharmaceutics, 2020
In pharmaceutical manufacturing of solid formulations, blending with a lubricant is a key process in preventing sticking during compression. Sticking not only results in tablets with a disfigured appearance but also brings about the interruption of continuous operations.
Hirotaka Ando +5 more
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In pharmaceutical manufacturing of solid formulations, blending with a lubricant is a key process in preventing sticking during compression. Sticking not only results in tablets with a disfigured appearance but also brings about the interruption of continuous operations.
Hirotaka Ando +5 more
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Drug Development and Industrial Pharmacy, 2023
The effects of granule size of raw materials on tablet hardness (TH) and weight (TW) in the continuous tablet manufacturing process (CTMP) were investigated using near-infrared spectroscopy (NIRS).Granule materials of different sizes were prepared by extrusion granulation from a standard granule formula powder containing lactose/starch and 4.5 ...
Makoto, Otsuka +3 more
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The effects of granule size of raw materials on tablet hardness (TH) and weight (TW) in the continuous tablet manufacturing process (CTMP) were investigated using near-infrared spectroscopy (NIRS).Granule materials of different sizes were prepared by extrusion granulation from a standard granule formula powder containing lactose/starch and 4.5 ...
Makoto, Otsuka +3 more
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Organic Process Research & Development, 2015
Quality by Design (QbD) is of paramount importance not only for patient safety but also for the timely and uninterrupted supply of products at affordable prices into the market. Both of these objectives can be achieved only through a robust process, and one of the major obstacles for developing a robust process is the quality of input materials and ...
Abdul Qayum Mohammed +4 more
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Quality by Design (QbD) is of paramount importance not only for patient safety but also for the timely and uninterrupted supply of products at affordable prices into the market. Both of these objectives can be achieved only through a robust process, and one of the major obstacles for developing a robust process is the quality of input materials and ...
Abdul Qayum Mohammed +4 more
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International Journal of Pharmaceutics, 2019
Multivariate data analysis (MVDA) and artificial neural networks (ANN) are supporting statistical methodologies required for successful development and manufacturing of drug products. To address this purpose, a complex dataset from 49 industrially produced capsules filled with pellets was first analyzed through the development of a multiple linear ...
Vidović, Sara +10 more
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Multivariate data analysis (MVDA) and artificial neural networks (ANN) are supporting statistical methodologies required for successful development and manufacturing of drug products. To address this purpose, a complex dataset from 49 industrially produced capsules filled with pellets was first analyzed through the development of a multiple linear ...
Vidović, Sara +10 more
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Journal of Pharmaceutical Sciences, 2017
Recent work established polymer strip films as a robust platform for delivery of poorly water-soluble drug particles. However, a simple means of manipulating rate of drug release from films with minimal impact on film mechanical properties has yet to be demonstrated.
Scott M, Krull +5 more
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Recent work established polymer strip films as a robust platform for delivery of poorly water-soluble drug particles. However, a simple means of manipulating rate of drug release from films with minimal impact on film mechanical properties has yet to be demonstrated.
Scott M, Krull +5 more
openaire +2 more sources
International Journal of Pharmaceutics
The potential of fine excipient materials to improve the aerodynamic performance of carrier-based dry powder inhalation (DPI) formulations is well acknowledged but not fully elucidated. To improve the understanding of this potential, we studied two fine excipient materials: micronized lactose particles and silica microspheres.
Mustafa M.A. Elsayed +6 more
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The potential of fine excipient materials to improve the aerodynamic performance of carrier-based dry powder inhalation (DPI) formulations is well acknowledged but not fully elucidated. To improve the understanding of this potential, we studied two fine excipient materials: micronized lactose particles and silica microspheres.
Mustafa M.A. Elsayed +6 more
openaire +4 more sources
Journal of Pharmaceutical Innovation, 2007
This work is an extension of the earlier work from this laboratory aimed at identifying raw material properties critical to the modeling of granule and ribbon properties as part of the optimization of roller (RC) compaction processes. The utility of roll gap (RG) and near-infrared (NIR) signal, specifically, the spectral slope, as process critical ...
Josephine L. P. Soh +5 more
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This work is an extension of the earlier work from this laboratory aimed at identifying raw material properties critical to the modeling of granule and ribbon properties as part of the optimization of roller (RC) compaction processes. The utility of roll gap (RG) and near-infrared (NIR) signal, specifically, the spectral slope, as process critical ...
Josephine L. P. Soh +5 more
openaire +1 more source