Results 121 to 130 of about 243,287 (266)

Therapeutic Reprogramming of Glioblastoma Phenotypic States Using Multifunctional Heparin Nanoparticles

open access: yesAdvanced Science, EarlyView.
This study presents heparin‐derived nanoparticles (HP‐NPs) as a novel precision medicine platform that combines therapeutic and delivery functions. HP‐NPs target drug‐resistant glioblastoma stem cells, reprogramming them into a drug‐sensitive phenotype and significantly reducing tumor progression.
Vadim Le Joncour   +14 more
wiley   +1 more source

Luminescent Nanocucurbits Enable Spatiotemporal Co‐Delivery of Hydrophilic and Hydrophobic Chemotherapeutic Agents

open access: yesAdvanced Science, EarlyView.
A cucurbit‐shaped luminescent nanoparticle (nanocucurbit) is engineered through the self‐assembly of polypeptides conjugated with aggregation‐induced emission (AIE) fluorophore. The resulting nanocucurbit exhibits approximately two‐fold higher cellular internalization efficiency compared to its spherical counterparts.
Ping Wei   +4 more
wiley   +1 more source

Micellization Behavior of Cetyltrimethylammonium bromide in Presence and Absence of Na2SO4 and MgSO4 in Aqueous media

open access: yesBibechana, 2016
Viscosity and surface tension measurements of cetyltrimethylammonium bromide (CTAB) in presence and absence of Na2SO4 and MgSO4 in aqueous media are reported.
Chom Nath Adhikari   +2 more
doaj  

Multiscale 3D Whole Joint Cellular and Molecular Mapping Reveals Disease‐Specific Neurovascular Plasticity Underlying the Structure‐Pain Relationship

open access: yesAdvanced Science, EarlyView.
This study presents MUSIC, a novel immunostaining and clearing method coupled with large‐field light sheet microscopy, enabling 3D high‐resolution cellular and molecular mapping of intact musculoskeletal joints across species and joint types. Using joint degenerative and injury models, disease‐specific neurovascular alterations are uncovered, revealing
Peng Chen   +18 more
wiley   +1 more source

Molecular Insights into Fungal Glycosylphosphatidylinositol Transamidase Complex

open access: yesAdvanced Science, EarlyView.
The glycosylphosphatidylinositol (GPI) biosynthesis pathway is critical for antifungal drug development. This study reports three cryo‐electron microscopy structures of fungal GPI transamidase (GPIT), captured in two substrate‐bound states and a novel dimeric assembly.
Zhengkang Hua   +12 more
wiley   +1 more source

A Robust Synthesis of Fluorosurfactants with Tunable Functionalities via a Two‐Step Reaction

open access: yesAdvanced Science, EarlyView.
The fluorosurfactants are synthesized through a two‐step reaction, and demonstrated excellent performance in droplet microfluidics. In addition, they exhibited tunable functionalities at the droplet interface via hydrogen bonding and coordination interactions.
Jiyuan Yao   +10 more
wiley   +1 more source

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