Results 101 to 110 of about 5,619,131 (294)

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

open access: yesAdvanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye   +11 more
wiley   +1 more source

Cross-Product Extensions of the Gene Ontology [PDF]

open access: yes, 2009
The Gene Ontology is being normalized and extended to include computable logical definitions. These definitions are partitioned into mutually exclusive cross-product sets, many of which reference other OBO Foundry ontologies.
Michael Bada   +7 more
core  

Marx and the Triple Ontological Criticism

open access: yes, 2021
The text in question aims to outline the triple ontological criticism that marks the “Marxian turn” in the work of Karl Marx. The article seeks to define the pertinence and evolution of Marxian theory, which has been engaged from a settling of scores against the imputations of idealistic redoubts.
Coelho, Henrique Leão, Sousa, Wesley
openaire   +1 more source

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

open access: yesAdvanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang   +8 more
wiley   +1 more source

An Advanced Clinical Ontology [PDF]

open access: yes, 2009
This article discusses a fundamental issues of medical ontology based on ontological theory. We focus on "anatomical structure of organs" and "abnormal states in the human body". On the basis of the investigation, we distinguish organ-
Riichiro Mizoguchi   +5 more
core   +1 more source

Transition from Critical Ontology To Metaphysical Foundations of Natural Science

open access: yesPensamiento. Revista de Investigación e Información Filosófica, 2015
The Critique of Pure Reason out lines an a priori ontology of nature. We find in the Critique the category of substance, which is totally a priori. However, the metaphysical principles of natural science come from the notion of matter, which is empirical.
Juan Csno De Pablo
doaj  

A Retinal Matrix Stiffening Model Reveals FAK‐Dependent Mechanotransduction in Pericytes Underlies Vascular Destabilization

open access: yesAdvanced Materials, EarlyView.
In this study, we show that retinal matrix stiffness is increased in diabetic mice. Using engineered human vascular models with controlled matrix stiffness, we demonstrate that stiffening activates focal adhesion kinase (FAK) signaling in pericytes, suppresses Notch signaling, and disrupts vascular morphology.
Emily Warren   +6 more
wiley   +1 more source

Ontology Winnowing: A Case Study on the AKT Reference Ontology

open access: yes, 2005
Many ontologies are built for the main purpose of representing a domain, rather than to meet the requirements of a specific application. When applications and services are deployed over an ontology, it is sometimes the case that only few parts of the ...
Harris, Steven   +2 more
core  

Developing Knowledge for Social Change: A Response to Critical Approaches to Science and Religion

open access: yesZygon
This is a response to the 2023 volume entitled Critical Approaches to Science and Religion. It examines the role of ontic commitments in shaping ethical claims. It also considers the possibility of objectivity in knowledge projects.
doaj   +2 more sources

A Coaxial Bioprinted Hydrogel With Semipermeable Sheath and Pro‐Chondrogenic Core for Articular Cartilage Repair

open access: yesAdvanced Materials, EarlyView.
A sheath‐core biomimetic hydrogel is engineered with a compartmentalized yet integrated architecture for synergistic multifunctionality. Its stiff, semipermeable sheath mimics the ECM's load‐bearing and protective roles, encapsulating a soft core that provides a pro‐chondrogenic microenvironment similar to the PCM.
Zheyuan Shi   +9 more
wiley   +1 more source

Home - About - Disclaimer - Privacy