Results 121 to 130 of about 5,619,131 (294)
Cybersecurity Ontology for Critical Infrastructures
Proceedings of the 9th International Joint Conference on Knowledge Discovery, Knowledge Engineering and Knowledge Management, 2017 Sandra Bergner, Ulrike Lechner
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Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
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John Searle’s Ontology of Money and Its Critics
John Searle has proposed one of the most influential contemporary accounts of social ontology. According to Searle, institutional facts are created by the collective assignment of a specific kind of function-status-function-to pre-existing objects. Thus, a piece of paper counts as money in a certain context because people collectively recognize it as ...
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Advanced Science, EarlyView.Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang +8 more
wiley +1 more source
Semantic foundations for digital twins: the contribution of ontological analysis
Frontiers in Computer ScienceDigital Twins (DTs) are revolutionizing industries by enabling real-time simulations, data-driven decision-making, and enhanced operational efficiency.
Mohammed Elhajj
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Advanced Science, EarlyView.The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang +11 more
wiley +1 more source
Ontology development for agricultural research knowledge management: a case study for Thai rice [PDF]
, 2009 The research is a pilot project aiming to develop a prototype ontology for plant production using Thai rice as a case study. It is expected that the development ontology will be a prototype model for others efforts aimed to develop plant production ...
Thunkijjanukij, Aree
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Advanced Science, EarlyView.In this study, we unveil a thymus‐brain endocrine axis wherein Tα1 engages HCRTR1 to inhibit RIPK3‐mediated necroptosis. This study nominates the Tal‐HCRTR1‐RIPK3 axis as a potent and clinically translatable therapeutic target for stroke and neurodegeneration.
Xinmei Kang +11 more
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The Scientific Ontology of Nikolai Hartmann versus the Existentialism of Martin Heidegger
Філософія освітиRelevance. The article presents a critical analysis of Martin Heidegger’s ontology through the lens of another outstanding ontologist, Nicolai Hartmann. The purpose of the study is to identify the fundamental differences between Heidegger’s and Hartmann’
Yehor Chumak
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Advanced Science, EarlyView.. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen +8 more
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