Results 241 to 250 of about 464,770 (292)

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Translating multi-omics into healthcare: requisites for scalable and equitable implementation. [PDF]

Hum Genomics
Tumiene B, Adams DR, Allaway R, Barrero MJ, Chan CH, Faundes V, Fear VS, Glezer P, Fuchs C, Groza T, Houwink EJF, Jamuar SS, Letinturier MCV, Lomash RM, Puri RD, Reichardt JKV, Mehrian-Shai R, van der Westhuizen FH, Varshney GK, Yamamoto S, Baynam G.   +20 more
europepmc   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Ontology-driven integration of advertised and operational capabilities in robots. [PDF]

Sci Rep
Naqvi MR, Sarkar A, Ameri F, Elmhadhbi L, Louge T, Karray MH.   +5 more
europepmc   +1 more source

SHACLens: a visualization workflow for SHACL violation exploration in knowledge graphs. [PDF]

Front Bioinform
Steinparz CA, Hinterreiter A, Bajraktari L, Sedlyarov V, Bauer MJ, Zichner T, Streit M.   +6 more
europepmc   +1 more source

ChEBI: re-engineered for a sustainable future. [PDF]

Nucleic Acids Res
Malik A, Arsalan M, Moreno C, Mosquera J, Félix E, Kizilören T, Muthukrishnan V, Zdrazil B, Leach AR, O'Boyle NM.   +9 more
europepmc   +1 more source

How Do Speech-Language Pathologists (SLPs) Know? A Survey of SLPs' Disciplinary Epistemology. [PDF]

Int J Lang Commun Disord
Duggleby Wenzel S, Charest M, Pritchard L.   +2 more
europepmc   +1 more source

Digital Biomarkers of Cytokine Release Syndrome: Scoping Review and Ontology Development of the Role and Relevance of Digital Measures Using a Mixed Methods Approach.

J Med Internet Res
Medberry CJ, Angel CZ, Batavia AS, Bradley S, Camerlingo N, Chen M, Datoo M, Kamdar P, Koenig E, Kusters L, Marquez C, Nukala U, Pettinati M, Phillips R, Sanchez DP, Shafagati N, Siegelman J, Stewart M, Varga C, Vandendriessche B, Wilkes M, Wolff-Hughes DL, Zahavi D, Zorman S, McClenahan SJ.   +24 more
europepmc   +1 more source

Critical realism, critical discourse analysis, and the aporetics of a critical ontology

, 2010
openaire   +1 more source