Results 21 to 30 of about 184,324 (258)
Ontology-Based Critical Infrastructure Modeling and Simulation [PDF]
, 2009 This paper describes a knowledge-based system (KBS) designed to support a federated environment for simulating critical infrastructure models. A federation of simulators is essentially a “system of systems,” where each simulator represents an entity that operates independently with its own behavior and purpose.
Masucci V. +4 more
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Critical realism and the ontology of persons [PDF]
Journal of Critical Realism, 2020 In this article, Roy Bhaskar suggests how critical realism might facilitate the understanding of persons and improve their lives.
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Journal of Biomedical Semantics, 2018 Ontologies are critical to data/metadata and knowledge standardization, sharing, and analysis. With hundreds of biological and biomedical ontologies developed, it has become critical to ensure ontology interoperability and the usage of interoperable ...
Yongqun He +5 more
doaj +1 more source
An Ontology-Based Approach to Aid STPA Analysis
IEEE Access, 2023 The safety-critical systems we are building today employ software, use physical and cybernetic components, and have more interactions (including hierarchical controllers). Systems-Theoretic Process Analysis (STPA) is a hazard analysis method that is used
Andrei Carniel +2 more
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Вісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетіїThe article examines the terminological challenges that any future translation project of the works of the semi-forgotten German philosopher N. Hartmann, specifically Zur Grundlegung der Ontologie, into Ukrainian may encounter.
Marko Mushenko, Hanna Dubova
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REFLECTIONS ON FOUCAULT’S CONCEPT OF CRITICAL ONTOLOGY
Bogazici Journal, 2006 Bu makale, Michel Foucault'nun eleştirel ontoloji kavramı üzerinde yoğunlaşmaktadır. Martin Heidegger ve Hannah Arendt kaynaklı sorularla, karşı karşıya getirilerek, eleştirel ontoloji kavramının teorik kıymeti vurgulanmaktadır. Foucault'da eleştirel ontoloji öncelikle bir "felsefi ethos" ve "felsefi tutum"dur.
openaire +3 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source