Results 41 to 50 of about 5,619,131 (294)

Critical Edition Ontology: a conceptual model for digital critical editions

Umanistica Digitale
Over the last thirty years, In the field of digital philology, several generic IT tools have been developed to produce digital scholarly editions (DSE). However, the majority of DSEs continue to be produced using custom-developed tools.
Chiara Martignano
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Fonamentar la crítica social: de l'enteniment al patiment i viceversa

Digithum, 2019
Aquest article analitza críticament les filosofies socials crítiques de John Dewey i Axel Honneth per tal de ressaltar dues fonts normatives diferents de conflictes socials: l'enteniment científic i el patiment social.
Onni Hirvonen
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Battery Value Chain Ontology (BVCO)

, 2023
What's Changed <ul> <li>improve process structure and detail industrial production steps by @LukasGold in <a href="https://github.com/Battery-Value-Chain-Ontology/ontology/pull/2">https://github.com/Battery-Value-Chain-Ontology/ontology/
Stier, Simon, Gold, Lukas
core   +1 more source

Mediatization Research and Causality: Toward a Critical Realist Ontology

International Journal of Communication, 2022
Mediatization research has been identified as an influential new approach in media and communication studies. However, being a theory of change, a proper discussion about causality and its correlated ontology foundations must be fundamental.
Sebastián Ansaldo
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

A fuzzy ontology modeling for case base knowledge in diabetes mellitus domain

Engineering Science and Technology, an International Journal, 2017
Knowledge-Intensive Case-Based Reasoning Systems (KI-CBR) mainly depend on ontologies. Ontology can play the role of case-base knowledge. The combination of ontology and fuzzy logic reasoning is critical in the medical domain.
Shaker El-Sappagh, Mohammed Elmogy
doaj   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source