Results 71 to 80 of about 9,664,331 (394)

Exploring the evidence for the use of protein biomarkers of muscular damage and disease progression in Duchenne and Becker muscular dystrophy: a systematic review and meta-analysis protocol

BMJ Open
Introduction Duchenne and Becker muscular dystrophies (DMD and BMD) are devastating conditions characterised by progressive muscle degeneration and weakness.
Stefania Mondello, Pietro Spitali, Alan J Russell, Amelia McGill, Ange Lu, Ramona Belfiore-Oshan, Paige B Martin   +6 more
doaj   +1 more source

Worm algorithms for classical statistical models [PDF]

, 2001
We show that high-temperature expansions may serve as a basis for the novel approach to efficient Monte Carlo simulations. "Worm" algorithms utilize the idea of updating closed path configurations (produced by high-temperature expansions) through the ...
Boris Svistunov, E. I. Pollock, G. Parisi, H. G. Ballesteros, H. G. Evertz, H. W. J. Blöte, H. Yahata, J. Machta, J. Salas, K. Kawasaki, M. Hasenbusch, N. Metropolis, N. V. Prokof'ev, Nikolay Prokof'ev, R. H. Swendsen, S. K. Ma, U. Wolff, V. A. Kashurnikov, X.-J. Li   +18 more
core   +3 more sources

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Addressing the need for standardization of symptomatic medication documentation in Parkinson's disease clinical research: A call to action

Journal of Parkinson’s Disease
People with Parkinson's disease (PD) are prescribed a variety of medications to mitigate symptoms and improve their quality of life. These symptomatic therapies cover a range of pharmacological classes, including classical dopaminergic treatments, other ...
Mikayla Spott, Monica Javidnia, Anne Pedata, Martijn Müller, Laura Carrillo, Tanya Simuni, Gennaro Pagano, Kevin Kwok, Klaus Romero, Diane Stephenson   +9 more
doaj   +1 more source

Molecular Neuroimaging of the Dopamine Transporter as a Patient Enrichment Biomarker for Clinical Trials for Early Parkinson's Disease

Clinical and Translational Science, 2019
The Critical Path for Parkinson's (CPP) Imaging Biomarker and Modeling and Simulation working groups aimed to achieve qualification opinion by the European Medicines Agency (EMA) Committee for Medical Products for Human Use (CHMP) for the use of baseline
Klaus Romero, Daniela Conrado, Jackson Burton, Timothy Nicholas, Vikram Sinha, Sreeraj Macha, Malidi Ahamadi, Jesse Cedarbaum, John Seibyl, Kenneth Marek, Peter Basseches, Derek Hill, Ed Somer, Jill Gallagher, David T. Dexter, Arthur Roach, Diane Stephenson, for the Critical Path for Parkinson's (CPP) Consortium, the Parkinson's Progression Markers Initiative (PPMI)   +18 more
doaj   +1 more source

Improving parallel program performance using critical path analysis [PDF]

, 1989
A programming tool that performs analysis of critical paths for parallel programs has been developed. This tool determines the critical path for the program as scheduled onto a parallel computer with P processing elements, the critical path for the ...
Bic, Lubomir, Gajski, Daniel D., Kwan, Andrew W.   +2 more
core  

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Functional integral approach to multipoint correlators in 2d critical systems [PDF]

, 1996
We extend a previously developed technique for computing spin-spin critical correlators in the 2d Ising model, to the case of multiple correlations. This enables us to derive Kadanoff-Ceva's formula in a simple and elegant way. We also exploit a doubling
C M Naón, Cabra D, Dotsenko Vl, Enting I, Ferrell R A, Luther A, Naón C M, Naón C M, Naón C M, Schroer B, Thirring W, V I Fernández   +11 more
core   +2 more sources

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source

Individual differences in human path integration abilities correlate with gray matter volume in retrosplenial cortex, hippocampus, and medial prefrontal cortex [PDF]

, 2017
Humans differ in their individual navigational abilities. These individual differences may exist in part because successful navigation relies on several disparate abilities, which rely on different brain structures.
Aselcioglu, Irem, Chrastil, Elizabeth R., Hasselmo, Michael E., Sherrill, Katherine R., Stern, Chantal E.   +4 more
core   +1 more source