Results 101 to 110 of about 2,386,191 (312)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Fatigue assessment of a FSAE car rear upright by a closed form solution of the critical plane method

Fracture and Structural Integrity
Material fatigue is extensively discussed and researched within scientific and industrial communities. Fatigue damage poses a significant challenge for both metallic and non-metallic components, often resulting in unexpected failures of in-service parts.
A. Chiocca, M. Sgamma, F. Frendo, F. Bucchi, G. Marulo   +4 more
doaj   +1 more source

Renormalized field theory and particle density profile in driven diffusive systems with open boundaries

, 1996
We investigate the density profile in a driven diffusive system caused by a plane particle source perpendicular to the driving force. Focussing on the case of critical bulk density $\bar{c}$ we use a field theoretic renormalization group approach to ...
B. Derrida, B. Derrida, B. Schmittmann, C. De Dominicis, C. De Dominicis, F. Spitzer, G. Schütz, H. K. Janssen, H. K. Janssen, H. K. Janssen, H. K. Janssen, H. K. Janssen, H. K. Janssen, H. van Beijeren, H. W. Diehl, H. W. Diehl, H. W. Diehl, H. W. Diehl, H. W. Diehl, H. W. Diehl, H. W. Diehl, H. W. Diehl, H. W. Diehl, H. W. Diehl, J. Krug, K. Oerding, K. Symanzik, P. C. Martin, P. L. Garrido, R. Bausch, R. K. P. Zia, S. Dietrich, S. Katz, V. Becker   +33 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Multiaxial Fatigue Lifetime Estimation Based on New Equivalent Strain Energy Damage Model under Variable Amplitude Loading

Crystals
The largest normal stress excursion during contiguous turn time instants of the maximum torsional stress is presented as an innovative path-independent fatigue damage quantity upon the critical plane, which is further employed for characterizing fatigue ...
Zhi-Qiang Tao, Xiangnan Pan, Zi-Ling Zhang, Hong Chen, Li-Xia Li   +4 more
doaj   +1 more source

Multiaxial Fatigue Life Calculation Model for Engineering Components in Rolling-Sliding Contact

MATEC Web of Conferences, 2018
Number of important engineering components and elements such as gears, rollers, bearings operate in conditions of rolling-sliding contact loading. Determination of fatigue lives of such components and elements is very important for engineering practice ...
Basan Robert, Marohnić Tea
doaj   +1 more source

Stiffness dependence of critical exponents of semiflexible polymer chains situated on two-dimensional compact fractals

, 2009
We present an exact and Monte Carlo renormalization group (MCRG) study of semiflexible polymer chains on an infinite family of the plane-filling (PF) fractals. The fractals are compact, that is, their fractal dimension $d_f$ is equal to 2 for all members
C. Vanderzande, Ivan Živić, Sava Milošević, Sunčica Elezović-Hadžić, V. Privman   +4 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source