Results 81 to 90 of about 15,117,675 (273)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Fatigue assessment of a FSAE car rear upright by a closed form solution of the critical plane method
Fracture and Structural IntegrityMaterial fatigue is extensively discussed and researched within scientific and industrial communities. Fatigue damage poses a significant challenge for both metallic and non-metallic components, often resulting in unexpected failures of in-service parts.
A. Chiocca +4 more
doaj +1 more source
Lost and Finding: Experiences of Newly Graduated Critical Social Workers [PDF]
, 2019 The first year of social work practice can be very stressful for new practitioners. Practice develops in response to the meaning we place on what we do and on our professional goals.
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
CrystalsThe largest normal stress excursion during contiguous turn time instants of the maximum torsional stress is presented as an innovative path-independent fatigue damage quantity upon the critical plane, which is further employed for characterizing fatigue ...
Zhi-Qiang Tao +4 more
doaj +1 more source
International Journal of Fatigue, 2000 A new energy-based approach for predicting constant amplitude multiaxial fatigue life is described. The approach is based on cyclic plastic and elastic strain energy densities and takes into account effects of stress-state and mean stresses. A wide range of test data is used to evaluate the approach as well as a critical plane approach based on maximum
Jinsoo Park, Drew Nelson
openaire +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Finite element modeling and critical plane analysis of a cut-and-chip experiment for rubber
, 2021 Rubber surfaces exposed to concentrated, sliding impacts carry large normal and shearing stresses that can cause damage and the eventual removal of material from the surface.
Mars, William V. +4 more
core +1 more source
Multiaxial Fatigue Life Calculation Model for Engineering Components in Rolling-Sliding Contact
MATEC Web of Conferences, 2018 Number of important engineering components and elements such as gears, rollers, bearings operate in conditions of rolling-sliding contact loading. Determination of fatigue lives of such components and elements is very important for engineering practice ...
Basan Robert, Marohnić Tea
doaj +1 more source
Bekentenissen van een Decaan [PDF]
, 2012 Tussen Augustinus en Rousseau is de zelfbeschouwing verschoven van Belijdenis naar Bekentenis, van een theocratische context naar een psychologische. Het is de vraag of het daaruit resulterende egocentrisme van de moderne tijd vooruitgang impliceert.
Koops, W. +3 more
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