Results 121 to 130 of about 1,342,909 (347)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

open access: yesMolecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim   +11 more
wiley   +1 more source

Infinitely many positive solutions for p-Laplacian equations with singular and critical growth terms

open access: yesBoundary Value Problems
In this paper, we study the existence of multiple solutions for the following nonlinear elliptic problem of p-Laplacian type involving a singularity and a critical Sobolev exponent { − Δ p u = u p ∗ − 1 + λ | u | γ − 1 u , in Ω , u = 0 , on ∂ Ω ...
Chen-Xi Wang, Hong-Min Suo
doaj   +1 more source

Editorial Conclusion for the Special Issue “New Theory and Applications of Nonlinear Analysis, Fractional Calculus and Optimization”

open access: yesAxioms
Nonlinear analysis has widespread and significant applications in many areas at the core of many branches of pure and applied mathematics and modern science, including nonlinear ordinary and partial differential equations, critical point theory ...
Wei-Shih Du
doaj   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

Minimax principles for critical-point theory in applications to quasilinear boundary-value problems

open access: yesElectronic Journal of Differential Equations, 2000
Using the variational method developed by the same author in [7], we establish the existence of solutions to the equation $-Delta_p u = f(x,u)$ with Dirichlet boundary conditions.
A. R. El Amrouss, M. Moussaoui
doaj  

Downregulation of O‐GlcNAcylation enhances etoposide‐induced p53‐mediated apoptosis in HepG2 human liver cancer cells

open access: yesFEBS Open Bio, EarlyView.
Etoposide, a topoisomerase II inhibitor, reduces O‐GlcNAcylation in HepG2 liver cancer cells. Further inhibition of O‐GlcNAc transferase by OSMI‐1 enhanced etoposide‐induced apoptosis, lowering the IC50 for viability and increasing the EC50 for cytotoxicity.
Jaehoon Lee   +5 more
wiley   +1 more source

Multiple solutions of nonlinear fractional elliptic equations via Morse theory

open access: yesElectronic Journal of Differential Equations, 2017
This article concerns the existence and multiplicity of weak solutions of the nonlinear fractional elliptic problem. We extend some well known results of semilinear Laplacian equations to the nonlocal fractional setting. Using the variational methods
Wei Qi, Lin Zhao, Xingjie Yan
doaj  

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