Results 51 to 60 of about 1,342,909 (347)

Periodic solutions to a class of distributed delay differential equations via variational methods

open access: yesAdvances in Nonlinear Analysis, 2023
In this article, we study the existence of periodic solutions to a class of distributed delay differential equations. We transform the search for periodic solutions with the special symmetry of a delay differential equation to the problem of finding ...
Xiao Huafeng, Guo Zhiming
doaj   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Theory of the Many-Body Localization Transition in One-Dimensional Systems

open access: yesPhysical Review X, 2015
We formulate a theory of the many-body localization transition based on a novel real-space renormalization group (RG) approach. The results of this theory are corroborated and intuitively explained with a phenomenological effective description of the ...
Ronen Vosk, David A. Huse, Ehud Altman
doaj   +1 more source

Solving the 2D SUSY Gross-Neveu-Yukawa model with conformal truncation

open access: yesJournal of High Energy Physics, 2021
We use Lightcone Conformal Truncation to analyze the RG flow of the two-dimensional supersymmetric Gross-Neveu-Yukawa theory, i.e. the theory of a real scalar superfield with a ℤ2-symmetric cubic superpotential, aka the 2d Wess-Zumino model.
A. Liam Fitzpatrick   +3 more
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Sign-changing solutions for some nonlinear problems with strong resonance

open access: yesBoundary Value Problems, 2011
By means of critical point and index theories, we obtain the existence and multiplicity of sign-changing solutions for some elliptic problems with strong resonance at infinity, under weaker conditions.
Qian Aixia
doaj  

Mixed boundary value problems involving Sturm–Liouville differential equations with possibly negative coefficients

open access: yesBoundary Value Problems
This paper is devoted to the study of a mixed boundary value problem for a complete Sturm–Liouville equation, where the coefficients can also be negative. In particular, the existence of infinitely many distinct positive solutions to the given problem is
Gabriele Bonanno   +2 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

open access: yesFEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp   +5 more
wiley   +1 more source

Sing-changing solutions for nonlinear problems with strong resonance

open access: yesElectronic Journal of Differential Equations, 2012
Using critical point theory and index theory, we prove the existence and multiplicity of sign-changing solutions for some elliptic problems with strong resonance at infinity, under weaker conditions than in the references.
Aixia Qian
doaj  

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

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