Results 131 to 140 of about 1,806,849 (306)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Local Matching of Surfaces Using Critical Points [PDF]
, 1984 The local matching problem on surfaces is: Given a pair of oriented surfaces in 3-space, find subsurfaces that are identical or complementary in shape. A heuristic method is presented for local matching that is intended for use on complex curved surfaces
Badler, Norman I, Radack, Gerald
core +1 more source
Thermodynamic stability and critical points in multicomponent mixtures with structured interactions. [PDF]
Phys Rev Res, 2022 Graf IR, Machta BB.
europepmc +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Critical Points in Lemke's Total Worker Health Calculus. [PDF]
J Occup Environ Med, 2021 Kelly KM +5 more
europepmc +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Critical points in the management of EGFR-mutated non-small cell lung cancer. [PDF]
J Thorac Dis, 2022 Casaluce F, Gridelli C.
europepmc +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
GROSS REGIONAL PRODUCT AS AN INDICATOR OF ECONOMIC SECURITY IN THE RUSSIAN ARCTIC
Север и рынок: формирование экономического порядкаThe growing interest in economic security reflects the rising number of threats and challenges facing the modern world. Within this field, particular attention is devoted to methods for assessing economic security.
Galina V. Kobylinskaya
doaj +1 more source