Results 131 to 140 of about 8,524,171 (298)
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Critical Points in Lemke's Total Worker Health Calculus. [PDF]
J Occup Environ Med, 2021 Kelly KM +5 more
europepmc +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Neurocognition and hypothyroidism: Critical points
Annals of Indian Psychiatry, 2017 Avinash De Sousa, Amresh Shrivastava
doaj +1 more source
Periodic solutions for a class of second-order Hamiltonian systems
Electronic Journal of Differential Equations, 2005 Multiplicity results for an eigenvalue second-order Hamiltonian system are investigated. Using suitable critical points arguments, the existence of an exactly determined open interval of positive eigenvalues for which the system admits at least three ...
Gabriele Bonanno, Roberto Livrea
doaj
Critical points of asymptotically quadratic functions [PDF]
, 1995 Existence results for critical points of asymptotically quadratic functions defined on Hilbert spaces are studied by using Morse-Conley index and pseudomonotone mappings.
Fečkan, Michal
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Existence of standing waves for Schrodinger equations involving the fractional Laplacian
Electronic Journal of Differential Equations, 2017 We study a class of fractional Schrodinger equations of the form $$ \varepsilon^{2\alpha}(-\Delta)^\alpha u+ V(x)u = f(x,u) \quad\text{in } \mathbb{R}^N, $$ where $\varepsilon$ is a positive parameter, $0 < \alpha < 1$, $2\alpha < N$, $(-\Delta ...
Everaldo S. de Medeiros +2 more
doaj
Critical points in the management of EGFR-mutated non-small cell lung cancer. [PDF]
J Thorac Dis, 2022 Casaluce F, Gridelli C.
europepmc +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source