Results 131 to 140 of about 1,797,780 (305)

Critical points of the L-curve.

, 2014
The critical point represents a 90% reduction in the maximum variation value, and points above the critical point correspond to key K-strings. The curves were generated based on randomly selected datasets with different numbers of species, (20, 40, 80 ...
Bin Liu (5899), Qingming Zhu (510809), Jianbo Yuan (510808)   +2 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Sign-changing critical points for noncoercive functionals

, 2016
We study the existence of infinitely many sign-changing critical points and nonexistence of critical points to a class of noncoercive ...
Wang, Youjun, Li, Zhouxin, Shen, Yaotian
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Critical points in the management of EGFR-mutated non-small cell lung cancer. [PDF]

J Thorac Dis, 2022
Casaluce F, Gridelli C.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Inductive Stimuli of the Startle Response and Critical Points of Psychological Treatment in a Severe Burn Patient. [PDF]

J Burn Care Res, 2022
Zhang Y, Luo L, Li P, Chen Z.
europepmc   +1 more source

On symmetric critical points of knot energies

, 2018
In this thesis, we examine the energy landscape of knot energies, trying to gain information about whether in a knot class there is more than one critical point. Motivated by the work of Cantarella et al.
Gilsbach, Alexandra Philippa
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

GROSS REGIONAL PRODUCT AS AN INDICATOR OF ECONOMIC SECURITY IN THE RUSSIAN ARCTIC

Север и рынок: формирование экономического порядка
The growing interest in economic security reflects the rising number of threats and challenges facing the modern world. Within this field, particular attention is devoted to methods for assessing economic security.
Galina V. Kobylinskaya
doaj   +1 more source