Results 121 to 130 of about 11,237,275 (282)

Flow chart outlining the elements of QbD (QTPP: Quality targeted product profile, CPPs: Critical process parameters, CQAs: Critical quality attributes, DOE: Design of experiments).

, 2018
Flow chart outlining the elements of QbD (QTPP: Quality targeted product profile, CPPs: Critical process parameters, CQAs: Critical quality attributes, DOE: Design of experiments).
Affiong Iyire (5921126), Afzal R. Mohammed (598394), Thomas J. Dennison (3070743), Ali Al-khattawi (598390), Eman Z. Dahmash (5921123), Hamad Al-Yami (5921129)   +5 more
core   +1 more source

mRNA vaccines: immunogenicity and quality characteristics

Journal of Nanobiotechnology
mRNA vaccine technology platform has evolved rapidly in recent years, which has emerged as an important direction in vaccine development. Establishing a quality control platform based on its Critical Quality Attributes (CQAs) is fundamental to ensuring ...
Yaru Quan, Huijie Yang, Wei Li, Linxian Li   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Consumer Behavior: Product Characteristics and Quality Perception [PDF]

Consumers rely on signals, both extrinsic and intrinsic attributes, to solve their asymmetric information problem regarding product quality. In this study an experiment is designed to evaluate how consumers assess quality perception in terms of specific ...
Pires Gonçalves, Ricardo
core  

Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate. [PDF]

Mol Ther Methods Clin Dev, 2023
Kumar P, Wang M, Kumru OS, Hickey JM, Sanmiguel J, Zabaleta N, Vandenberghe LH, Joshi SB, Volkin DB.   +8 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysis of the quality attributes used in establishing best value tenders in the UK social housing sector

, 2008
Purpose A number of studies have highlighted the problems and challenges that have been encountered with the analysis of best value and partnering tenders carried out in the UK public sector.
Dainty, A., Price, A., Phillips, S., Martin, J.   +3 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Online native hydrophobic interaction chromatography-mass spectrometry of antibody-drug conjugates

mAbs
Hydrophobic interaction chromatography (HIC) is commonly used to determine the drug-to-antibody ratio (DAR) and drug load distribution of antibody-drug conjugates (ADCs). However, identifying various DAR species separated by HIC is challenging due to the
Trevor Kempen, Lance Cadang, Yuchen Fan, Kelly Zhang, Tao Chen, Bingchuan Wei   +5 more
doaj   +1 more source

Impact of polymer chemistry on critical quality attributes of selective laser sintering 3D printed solid oral dosage forms. [PDF]

Int J Pharm X, 2023
Evgenii T, Valerie L, Michelle Å, Nicole DG, Maria S, Thomas K, Julian Q, Jonas L.   +7 more
europepmc   +1 more source