Results 81 to 90 of about 344,156 (288)

Stochastic epidemic models: a survey [PDF]

, 2009
This paper is a survey paper on stochastic epidemic models. A simple stochastic epidemic model is defined and exact and asymptotic model properties (relying on a large community) are presented.
Britton, Tom
core  

Oliver Wendell Holmes Jr.’s The Path of the Law – die Geburtsstunde des American Legal Realism [PDF]

, 2016
In diesem Artikel wird die Bedeutung des 1897 von Oliver Wendell Holmes Jr. veröffentlichten Aufsatzes The Path of the Law für die Entstehung des American legal realism sowie dessen Auswirkungen sowohl auf die juristische Ausbildung, als auch auf die ...
Kai Wörner
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Violations of local realism with quNits up to N=16 [PDF]

, 2001
Predictions for systems in entangled states cannot be described in local realistic terms. However, after admixing some noise such a description is possible.
A. Fine, A. Garg, A. Peres, A. Peres, A. Peres, A. Zeilinger, B. S. Tsirelson, C. Mattle, D. Kaszlikowski, Dagomir Kaszlikowski, I. D. Ivanovic, J. A. Nelder, J. Gondzio, J. Gondzio, J. Schwinger, M. Żukowski, M. Żukowski, N. Gisin, P. H. Eberhard, T. Durt, W. K. Wooters   +20 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Critical Realism: Philosophical Origin and Methodological Principles [PDF]

Islām va ̒ulūm-i ijtimā̒ī
During the past few decades, social sciences and humanities has been involved in numerous methodological and theoretical debates that is described as the paradigms war between positivists, interpretativists and critics.
Ahmad Mohammad Poor, Mahdi Alizadeh, Mahdi Rezayee   +2 more
doaj  

Crítica e cultura em marketing: repensando a disciplina

Cadernos EBAPE.BR
Este artigo descreve o processo de implementação de uma abordagem crítica em marketing, baseada no realismo crítico e desenvolvida na Inglaterra e no Brasil por um pesquisador brasileiro.
Alexandre Faria
doaj   +1 more source

Critical Realism versus Social Constructivism in International Relations [PDF]

The Journal of Philosophical Economics, 2011
This article discusses the methodological differences between the British school and the American school of international relations. It attempts to demonstrate that Susan Strange, representative of the British school, could be considered a critical ...
Roxana Bobulescu
doaj