Results 81 to 90 of about 4,716,782 (236)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Research as emancipatory: the case of Bhaskar's realism
, 2002 Bhaskar's critical realism offers a novel defense of the idea that by providing explanatory critiques of social formations, social research can emancipate us not merely from intellectual error but also from institutional oppression.
Hammersley, Martyn
core +3 more sources
Crítica e cultura em marketing: repensando a disciplina
Cadernos EBAPE.BREste artigo descreve o processo de implementação de uma abordagem crítica em marketing, baseada no realismo crítico e desenvolvida na Inglaterra e no Brasil por um pesquisador brasileiro.
Alexandre Faria
doaj +1 more source
Critical Realism versus Social Constructivism in International Relations [PDF]
The Journal of Philosophical Economics, 2011 This article discusses the methodological differences between the British school and the American school of international relations. It attempts to demonstrate that Susan Strange, representative of the British school, could be considered a critical ...
Roxana Bobulescu
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
The Argument from Underconsideration and Relative Realism [PDF]
, 2013 In this paper, through a critical examination of Wray’s version of the argument from underconsideration against scientific realism, I articulate a modest version of scientific realism.
Mizrahi, Moti
core
A critical realist methodology in empirical research: foundations, process, and payoffs
, 2021 This article describes and evaluates the application of an explicitly critical realist methodology to a quantitative doctoral research project on the causes of family homelessness in Australia.
Hastings, C, Catherine Hastings
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
, 2005 This paper first revisits the discussion between Tony Lawson and Sandra Harding in the journal Feminist Economics in light of the author’s own research into basic mechanisms of capitalist economies, research that has been influenced by feminist ...
Brown, G. +2 more
core
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source