Results 181 to 190 of about 6,939,801 (335)

A Critical Analysis of the Claims for Inter-Set Rest Intervals, Endogenous Hormonal Responses, Sequence of Exercise, and Pre-Exhaustion Exercise for Optimal Strength Gains in Resistance Training

, 2010
Ralph N. Carpinelli
openalex   +1 more source

When words become difficult: a critical reflection of the ‘MeBox’ method in understanding senior travellers’ responses to loss

, 2021
Uditha Ramanayake, Cheryl Cockburn‐Wootten, Alison McIntosh   +2 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Response to Letter to Editor "Critical Response to the Comments on the Critical Issue of Infant and Child Mortality in Afghanistan". [PDF]

Health Sci Rep
Chirumbolo S.
europepmc   +1 more source

Critical response of elastic-plastic SDOF systems with nonlinear viscous damping under simulated earthquake ground motions. [PDF]

Heliyon, 2019
Tamura G, Kojima K, Takewaki I.
europepmc   +1 more source

VO2 Responses to Running Speeds Above Intermittent Critical Speed

, 2012
Rafael Alves de Aguiar, Tiago Turnes, Rogério Santos de Oliveira Cruz, Fabrízio Caputo   +3 more
openalex   +2 more sources

Author response: Centrally expressed Cav3.2 T-type calcium channel is critical for the initiation and maintenance of neuropathic pain

, 2022
Sophie L. Fayad, Guillaume Ourties, Benjamin Le Gac, Baptiste Jouffre, Sylvain Lamoine, Antoine Fruquière, Sophie Laffray, Laïla Gasmi, Bruno Cauli, Christophe Mallet, Emmanuel Bourinet, Thomas Bessaïh, Régis C. Lambert, Nathalie Leresche   +13 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

A critical Response to "How firearm legislation impacts firearm mortality", A focused look at Canadian and Australian evidence. [PDF]

Health Policy Open
Langmann C.
europepmc   +1 more source

Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer. [PDF]

NPJ Syst Biol Appl, 2018
Ebhardt HA, Root A, Liu Y, Gauthier NP, Sander C, Aebersold R.   +5 more
europepmc   +1 more source