Results 91 to 100 of about 589,600 (262)

Critical speed estimated by statistically appropriate fitting procedures. [PDF]

open access: yesEur J Appl Physiol, 2021
Patoz A   +4 more
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Analysis of Dynamic Characteristics of Rotor Sail Using a 4DOF Rotor Model and Finite Element Model

open access: yesJournal of Marine Science and Engineering
The interest in wind-assisted ship propulsions (WASPs) is increasing to improve fuel efficiency and to reduce greenhouse gas emissions in ships. A rotor sail, one of the typical WASPs, can provide auxiliary propulsive force by rotating a cylinder-shaped ...
Dong Min Kim   +3 more
doaj   +1 more source

NOISE AS AN INDIRECT CRITERION FOR EVALUATING THE CRITICAL SPEED OF VEHICLE TIRE AT HYDROPLANING [PDF]

open access: yesAvtomobilʹnyj Transport (Harʹkov), 2017
An alternative method for determining the critical rolling speed of automobile tires with various tread patterns during hydroplaning is considered. The critical speed of the car at which the hydroplaning process takes place is determined.
V. Karpenko, K. Masliaiev
doaj  

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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