Results 91 to 100 of about 8,208,209 (253)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Viscoelastic Properties of Gallium-indium Alloy

Applied Rheology, 2018
The viscoelastic properties of a gallium-indium alloy in the pre-yield region make it easier to understand their characteristics, particularly the varying degrees of stiffness and damping properties.
Yang Yikun, Sun Shuaishuai, Tang Shi-Yang, Li Weihua, Zhang Shiwu   +4 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Mapping the strain-localization evolution of grain boundary and its interactions with slip/twin at the microscale

Journal of Magnesium and Alloys
Plastic strain in polycrystalline metals is highly localized in grain boundaries (GBs), slip bands (SBs) and twins. While extensive research has focused on intra-granular deformation mechanisms such as slip and twinning, strain localization at GBs has ...
Ran Ni, Saijun Huang, Lingling Fan, Kang Wei, Ying Zeng, Jiang Zheng, Qudong Wang, Hao Zhou, Dongdi Yin   +8 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Measurements of the critical strain for rippling in carbon nanotubes

, 2011
We report measurements of the bending stiffness in free standing carbon nanotubes, using atomic force microscopy inside a scanning electron microscope.
H. Jackman, P. Krakhmalev, K. Svensson
semanticscholar   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Study of Thickness Effect on Fracture Toughness of High Grade Pipeline Steel

MATEC Web of Conferences, 2016
The critical fracture toughness decreases when thickness of specimens increases and stress-strain field in crack tip start changing to plane strain state from plane stress state. In this paper, fracture toughness tests were carried. Based on the analysis
Zhang Hua, Zhang Hong, Zhao Xinwei, Wang Yalong, Li Na   +4 more
doaj   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

CRITICAL STRAIN DETERMINATION BASED ON THE EULER-FRESNEL JIG

, 2015
When considering a composite strip or plate under certain thermal and environmental conditions and loadings, there is a minimum strain threshold for the appearance of the first micro crack. The associated strain level is defined here as “critical strain”. There are various active displacement methods to measure this strain level (by tension and bending)
Koussios, Sotiris, Tazelaar, Katrin, Roozen, Bert, Alderliesten, René C., Beukers, Adriaan   +4 more
openaire   +3 more sources