Results 51 to 60 of about 3,824,363 (314)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The network structure of critical care transfers, 1993 [PDF]

, 2007
Poster presented at Annual MeetingBackground: In light of wide variations between hospitals in their quality of critical care, some have proposed moving patients to better quality.
Iwashyna, Theodore J.
core  

Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection

mBio, 2016
Anti-tumor necrosis factor alpha (anti-TNF-α) therapies have been increasingly used to treat inflammatory diseases and are associated with increased risk of invasive fungal infections, including Cryptococcus neoformans infection.
Jintao Xu, Alison J. Eastman, Adam Flaczyk, Lori M. Neal, Guolei Zhao, Jacob Carolan, Antoni N. Malachowski, Valerie R. Stolberg, Mohammed Yosri, Stephen W. Chensue, Jeffrey L. Curtis, John J. Osterholzer, Michal A. Olszewski   +12 more
doaj   +1 more source

Efficacy of Convalescent Plasma and Short Course of Corticosteroids in Patients with COVID-19

The University of Louisville Journal of Respiratory Infections, 2020
This study reported the efficacy of short-course corticosteroids and convalescent plasma (CP) transfusion in treating five patients with severe COVID-19 disease. Five adults (mean±standard deviation age: 70±9 years) with laboratory-confirmed COVID-19 and
Srikanth Ramachandruni, Po-Yang Tsou, D.C. Benetez, Gayathri Evani, Smitha Gudipati, Ramakrishna Chakilam, Polly Mock, Bharat Narasimhan, Dhanunjay Lakkireddy, Shekhar Raj   +9 more
doaj   +1 more source

Robust Mixed-Criticality Systems [PDF]

IEEE Transactions on Computers, 2018
Certification authorities require correctness and survivability. In the temporal domain this requires a convincing argument that all deadlines will be met under error free conditions, and that when certain defined errors occur the behaviour of the system is still predictable and safe.
Burns, Alan, Davis, Robert Ian, Baruah, Sanjoy, Bate, Iain John   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Fichte's System of Ethics : A Critical Guide

, 2021
The System of Ethics was published at the height of Fichte's academic career and marks the culmination of his philosophical development in Jena. Much more than a treatise on ethics narrowly construed, the System of Ethics presents a unified synthesis of ...
O. Ware, S. Bacin
core   +1 more source

Therapeutic potential of mitochondrial transplantation in modulating immune responses post-cardiac arrest: a narrative review

Journal of Translational Medicine
Background Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy, particularly effective in diseases characterized by mitochondrial dysfunction.
Tomoaki Aoki, Yusuke Endo, Eriko Nakamura, Cyrus E. Kuschner, Jacob Kazmi, Parmeshar Singh, Tai Yin, Lance B. Becker, Kei Hayashida   +8 more
doaj   +1 more source

Early stent fractures in superficial femoral artery resulting multiple pseudoaneurysm formation within one year: a case report

CVIR Endovascular, 2023
Background Though fracture is known complication of stenting, pseudoaneurysm asscoiated with stent fracture is an extremely rare complication. This has previoulsy been described to occur at least one or more years following initial stent placement.
Taylor Benedict, Esraa Hassan, Mikael Mir, Sydney Boike, Jidi Gao, Syed Anjum Khan   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source