Results 71 to 80 of about 3,824,363 (314)
Serum bilirubin and the risk of chronic obstructive pulmonary disease exacerbations
Respiratory Research, 2017 Background Bilirubin is a potent anti-oxidant and higher serum concentrations of bilirubin have been associated with better lung function, slower lung function decline, and lower incidence of chronic obstructive pulmonary disease (COPD).
Kirstin E. Brown +6 more
doaj +1 more source
Agile Testing and Critical Systems [PDF]
, 2011 The need to count on critical systems is growing day by day. Together with traditional domains such as medical devices, automotive, railway, aeronautical, space and telecommunications, new applications and services are coming up every day. Terms such as ubiquitous, pervasive, or autonomic computing, products under the general umbrella of smart devices ...
Jørgen Bøegh +2 more
openaire +1 more source
Entanglement in disordered systems at criticality [PDF]
physica status solidi c, 2008 AbstractEntanglement is a physical resource of a quantum system just like mass, charge or energy. Moreover it is an essential tool for many purposes of nowadays quantum information processing, e.g. quantum teleportation, quantum cryptography or quantum computation. In this work we investigate an extended system of N qubits. In our system a qubit is the
Varga, Imre +1 more
openaire +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
LifeBackground: Mitochondrial dysfunction, which is triggered by systemic ischemia–reperfusion (IR) injury and affects various organs, is a key factor in the development of post-cardiac arrest syndrome (PCAS).
Eriko Nakamura +9 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Critical Considerations for a Closed-loop Medication Administration System [PDF]
, 2020 In recent years, the serious consequences of medical error are realized by both healthcare practitioners and the public because of the critical direct injury towards the involved patients and the high indirect costs subsequently all around the world. The
Nilmini Wickramasinghe +3 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Identification of Critical Building Blocks in PLM System Implementation in the Automotive Supply Chain [PDF]
, 2017 In today’s industrialised world, manufacturers must adapt and evolve their Product Development (PD) processes through the adoption of bespoke ICT tools.
Zammit, J.P., Evans, R.D., Gao, J.X.
core +1 more source